高尿酸血症に合併した尿路結石に対するAllopurinolの長期使用経験

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タイトル別名
  • The Longterm Allopurinol Treatment of Hyperuricemia accompanied with Urolithiasis

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Seventeen patients with hyperuricemia accompanied with urolithiasis (8 with gout,9 without gout) were treated favorably with longterm administration of allopurinol for about 5 years to 10 years.<BR>No urolithiasis recurred throughout the therapeutic period.<BR>Of 17 patients,14 were hyperuricosuric and 3 normouricosuric.<BR>All patients were, however, normocalcemic. Calculus was recovered from 13 patients, which was according to the infrared spectra chiefly composed of calcium oxalate or phosphate in 9 patients (about 69 per cent). This means that allopurinol should be effective in the treatment of hyperuricosuric calcium urolithiasis. Depend on chemical composition of our cases, urinary tract stones accompanied with hyperuricemic patients were not always uric acid.<BR>It is recommended to analyze the underlying stone as far as possible for controlling the urinary pH value correspondingly to the nature of the stone.

収録刊行物

  • Uric acid research

    Uric acid research 4 (2), 150-160, 1980

    一般社団法人 日本痛風・核酸代謝学会

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