C-8. Glycosylated HemoglobinsおよびProteinの臨床的意義

• 稲田 満夫

  京都大学医学部第二内科

書誌事項

タイトル別名

• Clinical Utility of Glycosylated Hemoglobins (HbA<SUB>1</SUB>)

抄録

In normal subjects and patients with diabetes mellitus (type II), HbA_1a+b, HbA_1c and HbA₀ were fractionated by column chromatographic procedure of Trivelli et al and HbA₁ was determined by a commercial kit. Moreover, the total glycosylated hemoglobin (GHbA), glycosylated hemoglobin in HbA₀ (GHbA₀), glycosylated serum protein (GSP) and urinary glycosylated protein (UGP) were determined the colorimetric method of Gabbay et al, using thiobarbituric acid.<BR>Although there was no significant relation between HbA_1a+b levels and blood sugar levels, HbA_1c levels correlated significantly with the average blood sugar levels for several months proceeding the hemoglobin measurements. A significant correlation existed between HbA_1a+b and HbA_1c (r=+0.54, p<0.01), and, therefore, a striking correlation was evident in the plots of HbA_1a+b+HbA_1c against the mean blood sugar levels for 3 months prior to the hemoglobin measurements, which had a correlation coefficient of 0.79 (p<0.001). In addition, HbA₁ levels correlated significantly with GHbA (r=+0.89) and with GHbA₀(r=+0.94). On the other hand, the correlation coefficient between HbA₁ and GSP was only +0.41, although it was statistically significant (p<0.01). In particular, HbA₁ levels were not parallel to GSP levels in diabetics complicated with liver diseases. These results suggest that HbA₁ (HbA_1a+b+c) determinations by a commercial kit are a useful indicator for assessing the long-term blood glucose control in diabetics.<BR>In non-diabetics with nephrosis or chronic nephritis, the ratio of UGP to SGP averaged 0.95±0.17. The marked elevation of the ratio (1.95±0.53) was evident in diabetics with nephropathy, showing the elevated UGP levels in these patients. The finding suggest that the glycosylated protein might play a role in pathogenesis of diabetic nephropathy.

収録刊行物

• Proceedings of the Symposium on Chemical Physiology and Pathology

  Proceedings of the Symposium on Chemical Physiology and Pathology 21 (0), 127-129, 1982

  一般社団法人 日本臨床化学会

詳細情報

• CRID: 1390282679673173632
• NII論文ID: 130003355381
• DOI: 10.14921/jscc1971a.21.0_127
• ISSN: 21874085
• ISSN: 03863417
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可