痛風性関節炎における炎症性サイトカインの関与
書誌事項
- タイトル別名
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- Priming effect of TNF-α on the monosodium urate (MSU) crystalinduced production of reactive oxygen metabolites from poiymorphonucear leukocytes (PMNs).
- 合成尿酸塩結晶による好中球の活性酸素放出能に及ぼすTNF-αの影響
抄録
We examined whether inflammatory cytokines(I1-1β, IL-6, IL-8, TNF-α) which are believed to play a role in the pathogenesis of gouty arthritis, modulate the production of reactive oxygen metabolites from polymorphonuclear leukocytes (PMNs) induced by monosodium urate (MSU)crystals. The production of reactive oxygen metabolites was measured by a luminol dependent chemiluminescence (CL) assay. The CL response of PMNs stimulated by MSU crystals was significantly increased by preincubation of PMNs with TNF-α at 0.1 U/ml and higher concentrations, but not by preincubation with IL-1β, IL-6 or IL-8 at various concentrations (1-50ng/ml). The priming effect of TNF-αwas prominent at a low concentration of MSU crystals, suggesting that TNF-α plays a critical role in the initiation and progression of gouty arthritis.
収録刊行物
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- Purine and pyrimidine metabolism
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Purine and pyrimidine metabolism 19 (2), 93-98, 1995
一般社団法人 日本痛風・核酸代謝学会
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詳細情報 詳細情報について
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- CRID
- 1390282679742968832
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- NII論文ID
- 130003356426
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- COI
- 1:CAS:528:DyaK28XhtFShu7o%3D
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- ISSN
- 21870101
- 09162836
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可