多機能性蛋白YB-1-翻訳調節とノックアウトマウス

• 内海 健

  九州大学大学院医学研究院臨床検査医学

書誌事項

タイトル別名

• The pleiotropic function of the YB-1-Translational regulation and its knockout mouse

抄録

The Y-box binding protein (YB-1) represents the most evolutionary conserved nucleic acid binding protein. YB-1 is a member of the cold shock domain (CSD) protein family. The eukaryotic Y-box binding protein-1 (YB-1) is involved in the transcriptional and translational control of many biological processes including cell proliferation. In clinical studies, the cellular level of YB-1 has been shown to correlate with tumor growth and prognosis in cancers of the ovary, lung, and breast. Eukaryotic Y-box proteins also regulate gene expression at the translational level through their recognition of RNA, and therefore play critical roles in both mRNA turnover and translational control. YB-1 knockout mice show embryonic lethal and exhibit exencephaly associated with abnormal patterns of cell proliferation within the neuroepithelium. In this review, we will begin by briefly describing the characteristics of YB-1 and will then summarize the pleiotropic functions brought about via DNA-RNA transaction and proteinprotein interactions.

収録刊行物

• Japanese Journal of Clinical Chemistry

  Japanese Journal of Clinical Chemistry 36 (4), 296-302, 2007

  一般社団法人 日本臨床化学会

キーワード

• 翻訳調節
• cold shock
• ストレス
• ノックアウト

詳細情報

• CRID: 1390282679886976768
• NII論文ID: 130003357103
• DOI: 10.14921/jscc1971b.36.4_296
• COI: 1:CAS:528:DC%2BD2sXhtlejsL3M
• ISSN: 21874077
• ISSN: 03705633
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可