Pigmentation and behavior : potential association through pleiotropic genes in Drosophila

• Takahashi Aya

  Department of Biological Sciences, Tokyo Metropolitan University Research Center for Genomics and Bioinformatics, Tokyo Metropolitan University

書誌事項

タイトル別名

• Pigmentation and behavior: potential association through pleiotropic genes in <i>Drosophila</i>

抄録

The molecular basis of pigmentation variation within and among Drosophila species is largely attributed to genes in melanin biosynthesis pathway, which involves dopamine metabolism. Most of the genetic changes underlying pigmentation variations reported to date are changes at the expression levels of the structural genes in the pathway. Within D. melanogaster, changes in cis-regulatory regions of a gene, ebony, are responsible for the naturally occurring variation of the body pigmentation intensity. This gene is also known to be expressed in glia, and many visual and behavioral abnormalities of its mutants have been reported. This implies that the gene has pleiotropic functions in the nervous systems. In this review, current knowledge on pigmentation variation and melanin biosynthesis pathway are summarized, with some focus on pleiotropic features of ebony and other genes in the pathway. A potential association between pigmentation and behavior through such pleiotropic genes is discussed in light of cis-regulatory structure and pleiotropic mutations.

収録刊行物

• Genes & Genetic Systems

  Genes & Genetic Systems 88 (3), 165-174, 2013

  日本遺伝学会

キーワード

• dopamine
• <i>ebony</i>
• melanin biosynthesis pathway
• pigmentation
• pleiotropy

詳細情報

• CRID: 1390282680450872192
• NII論文ID: 10031194256
• NII書誌ID: AA11077421
• DOI: 10.1266/ggs.88.165
• COI: 1:STN:280:DC%2BC3sbntlOjsA%3D%3D
• ISSN: 18805779
• ISSN: 13417568
• NDL書誌ID: 024774157
• PubMed: 24025245
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I024774157
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可