Chronic Peripheral Administration of Kappa-Opioid Receptor Antagonist Advances Puberty Onset Associated with Acceleration of Pulsatile Luteinizing Hormone Secretion in Female Rats

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  • NAKAHARA Tatsuo
    Graduate School of Medicine, Nagoya University, Nagoya 466-8550, Japan
  • UENOYAMA Yoshihisa
    Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464-8601, Japan
  • IWASE Akira
    Graduate School of Medicine, Nagoya University, Nagoya 466-8550, Japan
  • OISHI Shinya
    Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan
  • NAKAMURA Sho
    Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan
  • MINABE Shiori
    Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464-8601, Japan
  • WATANABE Youki
    Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464-8601, Japan
  • DEURA Chikaya
    Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464-8601, Japan
  • NOGUCHI Taro
    Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan
  • FUJII Nobutaka
    Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan
  • KIKKAWA Fumitaka
    Graduate School of Medicine, Nagoya University, Nagoya 466-8550, Japan
  • MAEDA Kei-ichiro
    Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan
  • TSUKAMURA Hiroko
    Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464-8601, Japan

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Puberty in mammals is timed by an increase in gonadotropin-releasing hormone (GnRH) secretion. Previous studies have shown involvement of the two neuropeptides, kisspeptin and neurokinin B (NKB), in controlling puberty onset. Little is known about the role of the other key neuropeptide, dynorphin, in controlling puberty onset, although these three neuropeptides colocalize in the arcuate kisspeptin neurons. The arcuate kisspeptin neuron, which is also referred to as the KNDy neuron, has recently been considered to play a role as an intrinsic source of the GnRH pulse generator. The present study aimed to determine if attenuation of inhibitory dynorphin-kappa-opioid receptor (KOR) signaling triggers the initiation of puberty in normal developing female rats. The present study also determined if stimulatory NKB-neurokinin 3 receptor (NK3R) signaling advances puberty onset. Female Wistar-Imamichi rats were weaned and intraperitoneally implanted with osmotic minipumps filled with nor-binaltorphimine (nor-BNI), a KOR antagonist, or senktide, a NK3R agonist, at 20 days of age. Fourteen days of intraperitoneal infusion of nor-BNI or senktide advanced puberty onset, manifested as vaginal opening and the first vaginal estrus in female rats. Frequent blood sampling showed that nor-BNI significantly increased luteinizing hormone (LH) pulse frequency at 29 days of age compared with vehicle-treated controls. Senktide tended to increase this frequency, but its effect was not statistically significant. The present results suggest that the inhibitory input of dynorphin-KOR signaling plays a role in the prepubertal restraint of GnRH/LH secretion in normal developing female rats and that attenuation of dynorphin-KOR signaling and increase in NKB-NK3R signaling trigger the onset of puberty in female rats.

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