Dynamics of CD3⁺ T-cell Distribution Throughout the Estrous Cycle and Gestation in the Bovine Endometrium

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  • OHTA Tomokazu
    Laboratory of Veterinary Physiology, Department of Veterinary Medicine, Iwate University, Iwate 020-8550, Japan Laboratory for Immune Regulation, WPI Immunology Frontier Research Center, Osaka University, Osaka 565-0871, Japan
  • KOSHI Katsuo
    Laboratory of Veterinary Physiology, Department of Veterinary Medicine, Iwate University, Iwate 020-8550, Japan
  • USHIZAWA Koichi
    National Institute of Livestock and Grassland Science, Ibaraki 305-0901, Japan
  • HOSOE Misa
    Department of Developmental Biology, National Institute of Agrobiological Sciences, Ibaraki 305-8602, Japan
  • TAKAHASHI Toru
    Department of Developmental Biology, National Institute of Agrobiological Sciences, Ibaraki 305-8602, Japan
  • YAMAGUCHI Takahiro
    Laboratory of Innovative Green-Technology for Sustainable and Improving Beef Production, Department of Animal Biology, Graduate School of Agricultural Science, Tohoku University, Sendai 981-8555, Japan
  • KIZAKI Keiichiro
    Laboratory of Veterinary Physiology, Department of Veterinary Medicine, Iwate University, Iwate 020-8550, Japan
  • HASHIZUME Kazuyoshi
    Laboratory of Veterinary Physiology, Department of Veterinary Medicine, Iwate University, Iwate 020-8550, Japan

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タイトル別名
  • Dynamics of CD3<sup>+</sup> T-cell Distribution Throughout the Estrous Cycle and Gestation in the Bovine Endometrium

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T cells are the dominant lymphocytes in the endometrium and are considered to play a crucial role in implantation and in the maintenance of gestation through cytokine production and immune regulation. The mechanisms underlying immunoregulation at the feto-maternal interface are still obscure for this complex system. Understanding the role of T cells is a key factor in understanding the endometrial immune system. In this study, the distribution of endometrial CD3+ T cells in bovines was examined by immunohistochemical analysis. The estrous cycle and gestation was divided into 4 stages, and the number of CD3+-positive T cells was counted in each stage. CD3+ cells were found in the endometrium in significant numbers throughout the estrous cycle and were mostly located in the subepithelial area. The number of CD3+ cells significantly increased in the early and mid-luteal phases but decreased after implantation with the progression of gestation. No T cells were found in the placentome or specifically in the tissues near the fetus, including the trophoblastic area. In addition, very few T cells were found in stromal regions close to the myometrium of the endometrium. These findings suggest that downregulation of bovine endometrial CD3+ T-cell functions is closely related to the successful maintenance of gestation in a spatiotemporal manner.

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