In situ hybridization method reveals (pro)renin receptor expressing cells in the pituitary gland of rats: Correlation with anterior pituitary hormones
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- Takahashi Kazuhiro
- Department of Endocrinology and Applied Medical Science, Tohoku University Graduate School of Medicine
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- Yatabe Megumi
- Division of Cell Biology and Histology, Department of Anatomy, Jichi Medical University School of Medicine
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- Fujiwara Ken
- Division of Cell Biology and Histology, Department of Anatomy, Jichi Medical University School of Medicine
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- Hirose Takuo
- Department of Planning for Drug Development and Clinical Evaluation, Tohoku University Graduate School of Pharmaceutical Sciences and Medicine
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- Totsune Kazuhito
- Department of Social Welfare, Faculty of Synthetic Welfare, Tohoku Fukushi University
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- Yashiro Takashi
- Division of Cell Biology and Histology, Department of Anatomy, Jichi Medical University School of Medicine
書誌事項
- タイトル別名
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- <i>In Situ</i> Hybridization Method Reveals (Pro)renin Receptor Expressing Cells in the Pituitary Gland of Rats: Correlation with Anterior Pituitary Hormones
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抄録
Expression of (pro)renin receptor ((P)RR), a specific receptor for renin and prorenin, was studied in rat pituitary gland. In situ hybridization showed that cells expressing (P)RR mRNA were widely distributed in the anterior lobe and intermediate lobe of the pituitary gland. Double-staining using in situ hybridization for (P)RR mRNA and immunohistochemistry for the pituitary hormones showed that (P)RR mRNA was expressed in most of the GH cells and ACTH cells in the anterior lobe. (P)RR mRNA was also expressed in a few prolactin cells and TSH cells, but not in LH cells. The present study has shown for the first time the distribution of (P)RR mRNA expressing cells in the rat pituitary gland. These findings suggest that (P)RR plays physiological roles in the pituitary gland, such as the modulation of the pituitary hormone secretion.<br>
収録刊行物
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- Ａｃｔａ Ｈｉｓｔｏｃｈｅｍｉｃａ ｅｔ Ｃｙｔｏｃｈｅｍｉｃａ
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Ａｃｔａ Ｈｉｓｔｏｃｈｅｍｉｃａ ｅｔ Ｃｙｔｏｃｈｅｍｉｃａ 46 (1), 47-50, 2013
日本組織細胞化学会