Effect of Licorice Flavonoid Oil on Cholesterol Metabolism in High Fat Diet Rats

• HONDA Kazuhisa

  Department of Bioresource Science, Graduate School of Agricultural Science, Kobe University

• SANEYASU Takaoki

  Department of Bioresource Science, Graduate School of Agricultural Science, Kobe University

• HASEGAWA Shin

  Department of Bioresource Science, Graduate School of Agricultural Science, Kobe University

• TOMINAGA Yuji

  Frontier Biochemical and Medical Research Laboratories, Kaneka Corporation

• YOKOTA Shinichi

  Frontier Biochemical and Medical Research Laboratories, Kaneka Corporation

• KAMISOYAMA Hiroshi

  Department of Bioresource Science, Graduate School of Agricultural Science, Kobe University

抄録

Dietary licorice fravonoid oil (LFO) significantly decreased hepatic cholesterol and plasma lipoprotein cholesterol levels in high-fat diet rats. It significantly suppressed hydroxymethylglutaryl-CoA synthase activity and increased cholesterol 7α-hydroxylase activity. The low density lipoprotein receptor mRNA level was significantly increased by LFO. These results suggest that dietary LFO improves cholesterol metabolism in obese animals.

収録刊行物

• Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ

  Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ 77 (6), 1326-1328, 2013

  公益社団法人 日本農芸化学会

キーワード

• hydroxymethylglutaryl-CoA (HMG-CoA)
• cholesterol 7α-hydroxylase (CYP7A1)
• cholesterol
• low density lipoprotein (LDL)
• very low density lipoprotein (VLDL)

詳細情報

• CRID: 1390282681456512128
• NII論文ID: 10031184706
• NII書誌ID: AA10824164
• DOI: 10.1271/bbb.130104
• COI: 1:STN:280:DC%2BC3sjhtFWhug%3D%3D
• ISSN: 13476947
• ISSN: 09168451
• NDL書誌ID: 024647269
• PubMed: 23748774
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I024647269
• Web Site: http://www.tandfonline.com/doi/pdf/10.1271/bbb.130104
• Web Site: https://search.jamas.or.jp/link/ui/2014012753
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可