Sasa quelpaertensis and p-Coumaric Acid Attenuate Oleic Acid-Induced Lipid Accumulation in HepG2 Cells

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  • KIM Jeong-Hwan
    Department of Biology, Jeju National University
  • KANG Seong-Il
    Department of Biology, Jeju National University
  • SHIN Hye-Sun
    Department of Biology, Jeju National University
  • YOON Seon-A
    Department of Biology, Jeju National University
  • KANG Seung-Woo
    Department of Biology, Jeju National University
  • KO Hee-Chul
    Jeju Sasa Industry Development Agency, Jeju National University
  • KIM Se-Jae
    Department of Biology, Jeju National University Jeju Sasa Industry Development Agency, Jeju National University

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  • <i>Sasa quelpaertensis</i> and <i>p</i>-Coumaric Acid Attenuate Oleic Acid-Induced Lipid Accumulation in HepG2 Cells

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In this study, we examined the effects of Jeju dwarf bamboo (Sasa quelpaertensis Nakai) extract (JBE) and p-coumaric acid (CA) on oleic acid (OA)-induced lipid accumulation in HepG2 cells. JBE and CA increased the phosphorylation of AMP-activated protein kinase (AMPK), and acetyl-CoA carboxylase (ACC) and the expression of carnitine palmitoyl transferase 1a (CPT1a) in OA-treated HepG2 cells. Additionally, these compounds decreased sterol regulatory element-binding protein-1c (SREBP-1c), fatty acid synthase (FAS), and OA-induced lipid accumulation, suggesting that JBE and CA modulate lipid metabolism in HepG2 cells via the AMPK activation pathway.

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