Salmon Calcitonin Reduces Oxaliplatin-Induced Cold and Mechanical Allodynia in Rats

DOI Web Site Web Site PubMed 被引用文献3件 参考文献15件
  • Aoki Manahito
    Department of Molecular Pharmacology, School of Pharmaceutical Sciences, Kitasato University
  • Mori Asami
    Department of Molecular Pharmacology, School of Pharmaceutical Sciences, Kitasato University
  • Nakahara Tsutomu
    Department of Molecular Pharmacology, School of Pharmaceutical Sciences, Kitasato University
  • Sakamoto Kenji
    Department of Molecular Pharmacology, School of Pharmaceutical Sciences, Kitasato University
  • Ishii Kunio
    Department of Molecular Pharmacology, School of Pharmaceutical Sciences, Kitasato University

この論文をさがす

抄録

Oxaliplatin is commonly used anti-cancer drugs, but it frequently causes peripheral neuropathic pain. Recently, we reported that elcatonin, a synthetic analog of eel calcitonin, attenuated the oxaliplatin- and paclitaxel-induced cold and mechanical allodynia in rats. In the present study, we determined whether salmon calcitonin also had anti-allodynic effects on oxaliplatin-induced neuropathy in rats. The rats were treated with a single dose of oxaliplatin (6 mg/kg, intraperitoneally (i.p.)). Oxaliplatin resulted in cold and mechanical allodynia. We assessed the anti-allodynic effects of subcutaneously administered salmon calcitonin (20 U/kg/d) by cold stimulation (8°C) directly to the hind paw of the rats and by using the von Frey test. Salmon calcitonin almost completely reversed the effects of both cold and mechanical allodynia. These results suggest that salmon calcitonin is also useful for treatment of oxaliplatin-induced neuropathy clinically.

収録刊行物

被引用文献 (3)*注記

もっと見る

参考文献 (15)*注記

もっと見る

関連プロジェクト

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ