A Model of the Central Regulatory System for Cough Reflex

DOI Web Site Web Site PubMed 参考文献18件
  • Haji Akira
    Laboratory of Neuropharmacology, School of Pharmacy, Aichi Gakuin University
  • Kimura Satoko
    Laboratory of Neuropharmacology, School of Pharmacy, Aichi Gakuin University
  • Ohi Yoshiaki
    Laboratory of Neuropharmacology, School of Pharmacy, Aichi Gakuin University

この論文をさがす

抄録

Cough is an important defensive reflex that eliminates particles and secretions from the airways and protects the lower airways from the aspiration of foreign materials. Although the classical cough center is thought to be situated in or around the nucleus tractus solitarius (NTS) of the brainstem, our understanding of its profile is still incomplete. Accumulating evidence suggests a new concept of the central regulatory system for cough reflex. The cough pattern generator in the brainstem appears to be identical to the respiratory pattern generator and to function by reshaping of the discharge pattern of respiratory neurons. The generated cough motor task is transmitted to spinal motoneurons through the descending respiratory pathways. The cough-gating mechanism receives the peripheral tussigenic information through the relay neurons in the NTS and activates such a functionally flexible pattern generator by producing triggering signals. This review focuses on the cough-gating neurons that constitute the gating mechanism and play a crucial role in the generation of cough reflex.

収録刊行物

参考文献 (18)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ