Selective Androgen Receptor Modulator, YK11, Regulates Myogenic Differentiation of C2C12 Myoblasts by Follistatin Expression
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- Kanno Yuichiro
- Faculty of Pharmaceutical Sciences, Toho University
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- Ota Rumi
- Faculty of Pharmaceutical Sciences, Toho University
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- Someya Kousuke
- Faculty of Pharmaceutical Sciences, Toho University
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- Kusakabe Taichi
- Faculty of Pharmaceutical Sciences, Toho University
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- Kato Keisuke
- Faculty of Pharmaceutical Sciences, Toho University
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- Inouye Yoshio
- Faculty of Pharmaceutical Sciences, Toho University
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抄録
The myogenic differentiation of C2C12 myoblast cells is induced by the novel androgen receptor (AR) partial agonist, (17α,20E)-17,20-[(1-methoxyethylidene)bis-(oxy)]-3-oxo-19-norpregna-4,20-diene-21-carboxylic acid methyl ester (YK11), as well as by dihydrotestosterone (DHT). YK11 is a selective androgen receptor modulator (SARM), which activates AR without the N/C interaction. In this study, we further investigated the mechanism by which YK11 induces myogenic differentiation of C2C12 cells. The induction of key myogenic regulatory factors (MRFs), such as myogenic differentiation factor (MyoD), myogenic factor 5 (Myf5) and myogenin, was more significant in the presence of YK11 than in the presence of DHT. YK11 treatment of C2C12 cells, but not DHT, induced the expression of follistatin (Fst), and the YK11-mediated myogenic differentiation was reversed by anti-Fst antibody. These results suggest that the induction of Fst is important for the anabolic effect of YK11.
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 36 (9), 1460-1465, 2013
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001204632996224
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- NII論文ID
- 130003361518
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- NII書誌ID
- AA10885497
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- COI
- 1:STN:280:DC%2BC3sbksFGjtg%3D%3D
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 024792004
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- PubMed
- 23995658
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可