全身レベルの免疫細胞動態可視化による免疫系の理解

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  • 戸村 道夫
    京都大学医学研究科次世代免疫制御を目指す創薬医学融合拠点

書誌事項

タイトル別名
  • Understanding of Immune System by Visualization of Spatiotemporal Regulation of Immune Cells in the Entire Body
  • ゼンシン レベル ノ メンエキ サイボウ ドウタイ カシカ ニ ヨル メンエキケイ ノ リカイ

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抄録

  Immune system is high-dimensional integrated system distributed in the whole body. Many kinds of, total 1011 of immune cells are regulated by receiving appropriate signals in appropriate places. We have been attempting to understand immune system by revealing spatiotemporal regulation of immune cells at the whole body level by “Visualization of immune response in vivo”. Photoconvertible protein, “Kaede”-Tg mice allowed us to monitor cell-replacement and cell-movement in the whole body by marking cells with color of Kaede from green to red with exposure to violet light. It is applicable to small cell number populations in both lymphoid organs and also peripheral tissues under both normal and pathophysiological conditions. By using this system, we have demonstrated novel findings that “Naive CD4+ T cell recirculation is an active process that they recirculate through lymphoid organs to seek limited niche for interacting with endogenous antigens and upregulate their function.” and “Activated regulatory T cells emigrating from cutaneous immune response is responsible for termination of immune reponse.” I will introduce these new tools of us and would like to discuss what is needed to understand immune system in the entire body.<br>

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  • 薬学雑誌

    薬学雑誌 133 (4), 427-433, 2013-04-01

    公益社団法人 日本薬学会

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