A Spontaneous Epithelial-Myoepithelial Carcinoma of the Submandibular Gland in a Sprague-Dawley Rat
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- Li Yinghua
- Department of Pathology, Chemon Co., Ltd., 240 Nampyeongro, Yangji-Myeon, Cheoin-Gu, Yongin-Si, Gyeonggi-Do 449-826, Republic of Korea
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- Kim Hak-Soo
- Department of Pathology, Chemon Co., Ltd., 240 Nampyeongro, Yangji-Myeon, Cheoin-Gu, Yongin-Si, Gyeonggi-Do 449-826, Republic of Korea
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- Kang Min-Soo
- Department of Pathology, Chemon Co., Ltd., 240 Nampyeongro, Yangji-Myeon, Cheoin-Gu, Yongin-Si, Gyeonggi-Do 449-826, Republic of Korea
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- Shin Seo-Ho
- Department of Pathology, Chemon Co., Ltd., 240 Nampyeongro, Yangji-Myeon, Cheoin-Gu, Yongin-Si, Gyeonggi-Do 449-826, Republic of Korea
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- Koo Kyo-Hwan
- Department of Pathology, Chemon Co., Ltd., 240 Nampyeongro, Yangji-Myeon, Cheoin-Gu, Yongin-Si, Gyeonggi-Do 449-826, Republic of Korea
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- Kim Chul-Min
- Department of Pathology, Chemon Co., Ltd., 240 Nampyeongro, Yangji-Myeon, Cheoin-Gu, Yongin-Si, Gyeonggi-Do 449-826, Republic of Korea
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- Kim Kap-Ho
- Department of Pathology, Chemon Co., Ltd., 240 Nampyeongro, Yangji-Myeon, Cheoin-Gu, Yongin-Si, Gyeonggi-Do 449-826, Republic of Korea
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- Peck Charles
- Department of Pathology, Chemon Co., Ltd., 240 Nampyeongro, Yangji-Myeon, Cheoin-Gu, Yongin-Si, Gyeonggi-Do 449-826, Republic of Korea
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- Bae Han-Ik
- Department of Pathology, Kyungpook National University Medical Center, 474 Hakjeongdong, Buk-gu, Daegu 702-210, Republic of Korea
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- Jeong Ji Yun
- Department of Pathology, Kyungpook National University Medical Center, 474 Hakjeongdong, Buk-gu, Daegu 702-210, Republic of Korea
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- Kang Jin Seok
- Department of Biomedical Laboratory Science, Namseoul University, Cheonan, Chungcheongnam-do 331-707, Republic of Korea
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- Kang Boo-Hyon
- Department of Pathology, Chemon Co., Ltd., 240 Nampyeongro, Yangji-Myeon, Cheoin-Gu, Yongin-Si, Gyeonggi-Do 449-826, Republic of Korea
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抄録
The present report describes a rare case of spontaneous tumor of the salivary gland in a male Sprague-Dawley rat. The clinically confirmed mass rapidly developed in the cervical region between 19 and 21 weeks of age, and the animal was subsequently euthanized. At necropsy, a well-circumscribed nodule approximately 7 × 6 cm in diameter was found at the site of the salivary gland. The cut surface of the nodule was lobulated and soft and had a pinkish tan fish-flesh appearance. One large cyst (approximately 3 × 2 cm in size) containing reddish fluid was also present in the nodule. Histopathologically, the tumor, with a partially lobulated structure, was surrounded by a thin fibrous capsule. The majority of tumor cells formed a diffuse solid sheet structure that mainly consisted of small ovoid or spindle-shaped cells. In the tumor periphery, some cells were arranged in nest-like structures. Small duct-like structures lined with a monolayer of cuboidal epithelial cells resembling an intercalated duct or large polygonal clear cells with a myoepithelial component were also observed. Mitotic figures and necrotic foci were frequently observed in solid areas. Immunohistochemically, the tumor cells were positive for cytokeratin, epithelial membrane antigen, vimentin, p63, α-smooth muscle actin and calponin. The cells were negative for calcitonin, synaptophysin and chromogranin A. On the basis of these findings, the tumor was diagnosed as an epithelial-myoepithelial carcinoma originating from the luminal epithelial cells and myoepithelial cells in the submandibular gland.
収録刊行物
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- Journal of Toxicologic Pathology
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Journal of Toxicologic Pathology 26 (1), 67-72, 2013
日本毒性病理学会
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詳細情報 詳細情報について
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- CRID
- 1390282679390476160
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- NII論文ID
- 130003362358
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- NII書誌ID
- AN10232280
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- COI
- 1:STN:280:DC%2BC3snosVSitw%3D%3D
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- ISSN
- 1881915X
- 09149198
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- NDL書誌ID
- 024681691
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- PubMed
- 23723571
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可