Transition of Historical Control Data for High Incidence Tumors in F344 Rats

• KUROIWA Yuichi

  Toxicology Division, Gotemba Laboratory, BoZo Research Center Inc., 1284 Kamado, Gotemba, Shizuoka 412-0039, Japan

• ANDO Ryo

  Pathology Division, Gotemba Laboratory, BoZo Research Center Inc., 1284 Kamado, Gotemba, Shizuoka 412-0039, Japan

• KASAHARA Kenichiro

  Pathology Division, Gotemba Laboratory, BoZo Research Center Inc., 1284 Kamado, Gotemba, Shizuoka 412-0039, Japan

• NAGATANI Mariko

  Pathology Division, Gotemba Laboratory, BoZo Research Center Inc., 1284 Kamado, Gotemba, Shizuoka 412-0039, Japan

• YAMAKAWA Seiki

  Pathology Division, Gotemba Laboratory, BoZo Research Center Inc., 1284 Kamado, Gotemba, Shizuoka 412-0039, Japan

• OKAZAKI Shuzo

  Toxicology Division, Gotemba Laboratory, BoZo Research Center Inc., 1284 Kamado, Gotemba, Shizuoka 412-0039, Japan

抄録

Historical control data of tumor incidence were collected from the control groups (215 animals of each sex) in four recent carcinogenicity studies that were started between 2005 to 2009 (terminally sacrificed between 2007 and 2011) at BoZo Research Center Inc. (Gotemba, Shizuoka, Japan) using Fischer 344 rats (F344/DuCrlCrlj). These data were compared to the previous historical control data (from 1990 to 2004, previously reported) in the same facility. In the results, the incidence of C-cell adenoma in the thyroid tended to increase in both sexes in recent years (30.8% for males and 24.4% for females in 2005–2009) as compared with the previous data (17.4% and 20.1% for males and 11.5% and 11.8% for females in 1990–1999 and 2000–2004, respectively). In addition, the incidences of pancreatic islet cell adenoma in males and uterine adenocarcinoma tended to increase from around 2000 and remained high in recent years (incidences of islet cell adenoma in males of 10.5%, 17.1% and 20.5% in 1990–1999, 2000–2004 and 2005–2009; incidences of uterine adenocarcinoma of 3.3%, 12.0% and 13.5% in 1990–1999, 2000–2004 and 2005–2009, respectively). There was no apparent difference in the incidence of other tumors.

収録刊行物

• Ｊｏｕｒｎａｌ　ｏｆ　Ｔｏｘｉｃｏｌｏｇｉｃ　Ｐａｔｈｏｌｏｇｙ

  Ｊｏｕｒｎａｌ　ｏｆ　Ｔｏｘｉｃｏｌｏｇｉｃ　Ｐａｔｈｏｌｏｇｙ 26 (2), 227-230, 2013

  日本毒性病理学会

キーワード

• historical control data
• F344 rat
• high incidence tumor

詳細情報

• CRID: 1390001204414141312
• NII論文ID: 130003362368
• NII書誌ID: AN10232280
• DOI: 10.1293/tox.26.227
• COI: 1:STN:280:DC%2BC3sfmslWhtw%3D%3D
• ISSN: 1881915X
• ISSN: 09149198
• NDL書誌ID: 024792501
• PubMed: 23914067
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I024792501
• Web Site: https://www.jstage.jst.go.jp/article/tox/26/2/26_2012-0048/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2014196880
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可