N-Methyl-N-nitrosourea-induced Renal Tumors in Rats : Immunohistochemical Comparison to Human Wilms Tumors

• YOSHIZAWA Katsuhiko

  Department of Pathology II, Kansai Medical University, Hirakata, Osaka 573-1010, Japan

• KINOSHITA Yuichi

  Department of Pathology II, Kansai Medical University, Hirakata, Osaka 573-1010, Japan Division of Pathology, Kansai Medical University Takii Hospital, Moriguchi, Osaka 570-8507, Japan

• EMOTO Yuko

  Department of Pathology II, Kansai Medical University, Hirakata, Osaka 573-1010, Japan Division of Pathology, Kansai Medical University Takii Hospital, Moriguchi, Osaka 570-8507, Japan

• KIMURA Ayako

  Department of Pathology II, Kansai Medical University, Hirakata, Osaka 573-1010, Japan

• UEHARA Norihisa

  Department of Pathology II, Kansai Medical University, Hirakata, Osaka 573-1010, Japan

• YURI Takashi

  Department of Pathology II, Kansai Medical University, Hirakata, Osaka 573-1010, Japan

• SHIKATA Nobuaki

  Division of Pathology, Kansai Medical University Takii Hospital, Moriguchi, Osaka 570-8507, Japan

• TSUBURA Airo

  Department of Pathology II, Kansai Medical University, Hirakata, Osaka 573-1010, Japan

書誌事項

タイトル別名

• <i>N</i>-Methyl-<i>N </i>-nitrosourea-induced Renal Tumors in Rats: Immunohistochemical Comparison to Human Wilms Tumors

抄録

N-Methyl-N-nitrosourea (MNU)-induced renal tumors in rats and Wilms tumors in humans were compared. Renal mesenchymal tumors (RMTs) and nephroblastomas (blastemal and epithelial components) in female Lewis rats treated with a single intraperitoneal injection of 50 mg/kg MNU at birth and Wilms tumors (blastemal, epithelial and mesenchymal components) in humans were analyzed for the expression of pancytokeratin (CK), vimentin, p63, α-smooth muscle actin (SMA), desmin, S-100, CD57, CD117/c-kit, Wilms tumor 1 protein (WT1) and β-catenin. The mesenchymal components of rat RMTs and human Wilms tumors expressed vimentin, SMA and β-catenin. The blastemal components of rat nephroblastomas and human Wilms tumors expressed vimentin, CD117/c-kit and β-catenin. The epithelial components of rat nephroblastomas and human Wilms tumors expressed vimentin and β-catenin. WT1 was expressed in different cellular components of rat tumors as compared with human Wilms tumors; the expression was seen in mesenchymal tumors and blastemal components of nephroblastomas in rats and epithelial components in human Wilms tumors. CK, p63 and CD57 were not expressed in rat RMTs or nephroblastomas, while CK and WT1 were expressed in epithelial components and CD57 was expressed in blastemal and epithelial components of human Wilms tumors. Rat and human tumors were universally negative for the expression of desmin and S-100. The immunohistochemical characteristics of rat renal tumors and human Wilms tumors may provide valuable information on the differences in renal oncogenesis and biology between the two species.

収録刊行物

• Ｊｏｕｒｎａｌ　ｏｆ　Ｔｏｘｉｃｏｌｏｇｉｃ　Ｐａｔｈｏｌｏｇｙ

  Ｊｏｕｒｎａｌ　ｏｆ　Ｔｏｘｉｃｏｌｏｇｉｃ　Ｐａｔｈｏｌｏｇｙ 26 (2), 141-148, 2013

  日本毒性病理学会

キーワード

• immunohistochemistry
• kidney
• <i>N</i>-methyl-<i>N</i>-nitrosourea
• nephroblastoma
• renal mesenchymal tumor
• Wilms tumor

詳細情報

• CRID: 1390282679390859648
• NII論文ID: 130003362369
• NII書誌ID: AN10232280
• DOI: 10.1293/tox.26.141
• COI: 1:STN:280:DC%2BC3sfmslWitg%3D%3D
• ISSN: 1881915X
• ISSN: 09149198
• NDL書誌ID: 024792369
• PubMed: 23914056
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I024792369
• Web Site: https://www.jstage.jst.go.jp/article/tox/26/2/26_2012-0049/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2014196869
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可