Neu2000 Potentiates a Kainate Response in Mouse Cortical Neurons

• Noh Jihyun

  Department of Brain and Cognitive Sciences, Ewha Womans University, Korea Deparment of Science Education, Dankook University, Korea

• Chung Jun-mo

  Department of Brain and Cognitive Sciences, Ewha Womans University, Korea

抄録

Neu2000, acting as an antioxidant with N-methyl-d-aspartate–receptor antagonism, demonstrates excellent protection against ischemic insults in rodents. In this study, we report that Neu2000 also dramatically enhances the activity of kainate (KA) receptors. Neu2000 non-competitively and reversibly potentiated KA-evoked responses in a voltage-independent manner, mainly by increasing the open probability of KA receptor channels.

収録刊行物

• Journal of Pharmacological Sciences

  Journal of Pharmacological Sciences 122 (2), 149-152, 2013

  公益社団法人 日本薬理学会

キーワード

• kainic acid
• voltage-clamp
• noise analysis

詳細情報

• CRID: 1390282680157683072
• NII論文ID: 10031185407
• NII書誌ID: AA11806667
• DOI: 10.1254/jphs.13023sc
• COI: 1:STN:280:DC%2BC3snmtVGjtQ%3D%3D
• ISSN: 13478648
• ISSN: 13478613
• NDL書誌ID: 024637939
• PubMed: 23698159
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I024637939
• Web Site: https://www.jstage.jst.go.jp/article/jphs/122/2/122_13023SC/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2014145718
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可