SLEにおけるB細胞機能異常

• 北郡 宏次

  京都大学大学院医学研究科　内科学講座　臨床免疫学

• 川端 大介

  京都大学大学院医学研究科　内科学講座　臨床免疫学

書誌事項

タイトル別名

• B cell abnormality in systemic lupus erythematosus

抄録

  B cells play central roles in pathogenesis of SLE through autoantibody production, autoantigen-presentation, cytokine production and activation of cognate T cells. Recently, a specific subset of B cells, which exerts immunoregulatory properties via IL-10 production was identified, and dysfunction of these B cells might involved in the pathogenesis of SLE. Currently, various therapies targeting B cells, such as B cell-depletive therapy and B cell regulation molecules seems promising, however, their efficacy and safety in the treatment of SLE should be carefully verified in the future. Because the pathogenesis varies in each patients with SLE, the advent of new era in which therapies can be selected based on an individual immune abnormality is waiting.<br>

収録刊行物

• 日本臨床免疫学会会誌

  日本臨床免疫学会会誌 35 (6), 495-502, 2012

  日本臨床免疫学会

キーワード

• Systemic lupus erythematosus
• B lymphocyte
• BLyS
• regulatory B cell
• molecular target treatment

詳細情報

• CRID: 1390282679630381568
• NII論文ID: 10031147893
• NII書誌ID: AN00357971
• DOI: 10.2177/jsci.35.495
• COI: 1:STN:280:DC%2BC3s3mvFyisg%3D%3D
• ISSN: 13497413
• ISSN: 09114300
• PubMed: 23291484
• Web Site: https://www.jstage.jst.go.jp/article/jsci/35/6/35_495/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2013248596
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可