Behavioral Performance at Early (4 Weeks) and Later (6 Months) Stages in Rats With Unilateral Medial Forebrain Bundle and Striatal 6-Hydroxydopamine Lesions
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- SUN Wei
- Department of Neurosurgery, Hamamatsu University School of Medicine
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- SUGIYAMA Kenji
- Department of Neurosurgery, Hamamatsu University School of Medicine
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- ASAKAWA Tetsuya
- Department of Neurosurgery, Hamamatsu University School of Medicine
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- ITO-YAMASHITA Tae
- Department of Neurosurgery, Hamamatsu University School of Medicine
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- NAMBA Hiroki
- Department of Neurosurgery, Hamamatsu University School of Medicine
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Our previous studies showed differences in striatal D2 receptor functional activity between two different rat parkinsonian models, with lesions induced by 6-hydroxydopamine injection in the striatum and in the medial forebrain bundle (MFB) at both early (4 weeks) and later (6 months) stages after lesioning. The present study compared behavioral changes, including rotational movements induced by methamphetamine and bromocriptine, and the stepping test, in both models at both stages. No differences in behavioral performance were observed between the early and later stages in both striatal and MFB lesion models, whereas simultaneous D2 receptor study showed dynamic change in D2 receptors in MFB lesion rats. Behavioral characteristics might be controlled by comprehensive effects of the whole dopaminergic system, instead of variation in a few parameters of the dopaminergic system. More behavioral tests of different mechanisms with simultaneous molecular studies are needed for evaluation of parkinsonian animal models and the efficacy of treatments.<br>
収録刊行物
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- Neurologia medico-chirurgica
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Neurologia medico-chirurgica 53 (1), 7-11, 2013
一般社団法人 日本脳神経外科学会
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詳細情報 詳細情報について
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- CRID
- 1390282680035187840
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- NII論文ID
- 10031138763
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- NII書誌ID
- AN00358613
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- DOI
- 10.2176/nmc.53.7
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- COI
- 1:STN:280:DC%2BC3szjt1Ojsg%3D%3D
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- ISSN
- 13498029
- 04708105
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- PubMed
- 23358162
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可