Post-ischemic Administration of Vascular Endothelial Growth Factor Inhibitor in a Rat Model of Cerebral Venous Infarction
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- MIYAKE Hitoshi
- Department of Neurosurgery, Nara Medical University
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- NAKAGAWA Ichiro
- Department of Neurosurgery, Nara Medical University
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- TAKESHIMA Yasuhiro
- Department of Neurosurgery, Nara Medical University
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- NISHIMURA Fumihiko
- Department of Neurosurgery, Nara Medical University
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- PARK Young-Su
- Department of Neurosurgery, Nara Medical University
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- NAKAMURA Mitsutoshi
- Department of Neurosurgery, Nara Medical University
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- NAKASE Hiroyuki
- Department of Neurosurgery, Nara Medical University
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抄録
Cerebral venous ischemia can result in severe brain edema. Inhibition of vascular endothelial growth factor (VEGF) activity by a neutralizing antibody can completely block the hypoxia-induced increase in vascular permeability. VEGF, which induces angiogenesis, also acts as a vascular permeability (VP) factor. We previously showed that inhibition of VEGF attenuates VP and reduces cerebral venous infarction (CVI) in the acute stage. The present study investigated the therapeutic time window during which inhibition of VEGF can reduce CVI in a rat two-vein occlusion (2-VO) model. A 2-VO model was created by photochemically occluding two adjacent cortical veins. Male Wistar rats (n = 42) were assigned to one of four groups: Group 1 was treated with a VEGF antagonist at 24 hours after 2-VO (n = 11); Group 2 was treated with phosphate-buffered solution (PBS) at 24 hours after 2-VO (n = 11); Group 3 was treated with a VEGF antagonist at 48 hours after 2-VO (n = 10); and Group 4 was treated with PBS at 48 hours after 2-VO (n = 10). The developing ischemic infarct was evaluated histologically at 7 days after 2-VO. CVI areas were significantly smaller in Group 1 than in Groups 2, 3, and 4 (p <0.05) but were similar when comparing Groups 3 and 4. Anti-VEGF therapy was effective in reducing CVI in rats if started within 24 hours after 2-VO.<br>
収録刊行物
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- Neurologia medico-chirurgica
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Neurologia medico-chirurgica 53 (3), 135-140, 2013
一般社団法人 日本脳神経外科学会
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詳細情報 詳細情報について
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- CRID
- 1390282680033469696
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- NII論文ID
- 10031138791
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- NII書誌ID
- AN00358613
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- COI
- 1:STN:280:DC%2BC3svpt1Ojsw%3D%3D
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- ISSN
- 13498029
- 04708105
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- PubMed
- 23524495
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- 本文言語コード
- en
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- データソース種別
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- JaLC
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- PubMed
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- 使用不可