Biosynthesis and biological function of sulfoglycolipids
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- HONKE Koichi
- Department of Biochemistry and Kochi System Glycobiology Center, Kochi University Medical School
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Sulfation confers negative charge on glycolipids and the attached sulfate group presents a part of determinants for the molecular interactions. Mammalian sulfoglycolipids are comprised of two major members, sulfatide (SO3-3Gal-ceramide) and seminolipid (SO3-3Gal-alkylacylglycerol). Sulfatide is abundant in the myelin sheath and seminolipid is unique to the spermatogenic cells. The carbohydrate moiety of sulfatide and seminolipid is biosynthesized via sequential reactions catalyzed by common enzymes: ceramide galactosyltransferase (CGT) and cerebroside sulfotransferase (CST). To elucidate the biological function of sulfoglycolipids, we have purified CST, cloned the CST gene, and generated CST-knockout mice. CST-null mice completely lack sulfoglycolipids all over the body. CST-null mice manifest some neurological disorders due to myelin dysfunction, an aberrant enhancement of oligodendrocyte terminal differentiation, and an arrest of spermatogenesis. CST-deficiency ameliorates L-selectin-dependent monocyte infiltration in the renal interstitial inflammation, indicating that sulfatide is an endogenous ligand of L-selectin. Studies on the molecular mechanisms underlying the biological events for which sulfoglycolipids are essential are ongoing.<BR><BR>(Communicated by Kunihiko SUZUKI, M.J.A.)
収録刊行物
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- Proceedings of the Japan Academy. Ser. B: Physical and Biological Sciences
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Proceedings of the Japan Academy. Ser. B: Physical and Biological Sciences 89 (4), 129-138, 2013
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詳細情報 詳細情報について
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- CRID
- 1390282679122300672
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- NII論文ID
- 130003365112
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- NII書誌ID
- AA00785485
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- COI
- 1:STN:280:DC%2BC3srkt1ymsg%3D%3D
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- ISSN
- 13492896
- 03862208
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- NDL書誌ID
- 024465111
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- PubMed
- 23574804
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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- PubMed
- CiNii Articles
- KAKEN
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- 使用不可