Preventive Effects of Black Soybean Seed Coat Polyphenols against DNA Damage in Salmonella typhimurium
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- ZHANG Tianshun
- Department of Agrobioscience, Graduate School of Agricultural Science, Kobe University
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- KAWABATA Kyuichi
- Organization of Advanced Science and Technology, Kobe University
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- KITANO Rei
- Department of Agrobioscience, Graduate School of Agricultural Science, Kobe University
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- ASHIDA Hitoshi
- Department of Agrobioscience, Graduate School of Agricultural Science, Kobe University
書誌事項
- タイトル別名
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- Preventive Effects of Black Soybean Seed Coat Polyphenols against DNA Damage in <i>Salmonella typhimurium</i>
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Black soybean seed coat is a rich source of polyphenols reported to have various physiological functions. The present study investigated the potential protective effects of polyphenolic extracts from black soybean seed coat on mutagen-induced DNA damage in Salmonella typhimurium. Results from the Ames test using Salmonella stains revealed that black soybean seed coat extract (BE) at 5000 µg/plate showed neither mutagenicity nor cytotoxicity. In contrast, BE, its component cyanidin 3-glucoside (C3G), or procyanidin-rich BE (PC-rich BE) dose-dependently inhibited B(a)P- and 4NQO-induced mutagenesis in the rank order: C3G > BE > PC-rich BE. At 5 μM/plate, C3G and procyanidins, the major polyphenols in BE, inhibited B(a)P-induced mutagenesis in TA 98 and TA 100 by 28 − 59%. They also inhibited 4NQO-induced mutagenesis by 26 − 56%. Collectively, we found that C3G and procyanidins, which are the main active compounds in BE, effectively protected against DNA mutagenic damage in Salmonella typhimurium.
収録刊行物
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- Food Science and Technology Research
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Food Science and Technology Research 19 (4), 685-690, 2013
公益社団法人 日本食品科学工学会
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詳細情報 詳細情報について
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- CRID
- 1390282679436483200
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- NII論文ID
- 10031189995
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- NII書誌ID
- AA11320122
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- ISSN
- 18813984
- 13446606
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可