Central Diabetes Insipidus in an HHV6 Encephalitis Patient with a Posterior Pituitary Lesion that Developed after Tandem Cord Blood Transplantation
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- Kawamoto Shinichiro
- Department of Internal Medicine, Rinku General Medical Center, Japan Department of Clinical and Laboratory Medicine, Osaka Medical College, Japan
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- Hatanaka Kazuo
- Department of Internal Medicine, Rinku General Medical Center, Japan Department of Hematology and Oncology, Wakayama Medical University, Japan
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- Imakita Masami
- Department of Pathology, Rinku General Medical Center, Japan
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- Tamaki Toshiharu
- Department of Internal Medicine, Rinku General Medical Center, Japan
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抄録
A 60-year-old myelodysplastic syndrome patient underwent tandem cord blood transplantation. The primary cord blood graft was rejected, and human herpesvirus 6 (HHV6) encephalitis developed after engraftment of secondary cord blood. Polyuria and adipsic hypernatremia were observed during treatment of the encephalitis. The patient died of bacteremia caused by methicillin-resistant Streptococcus epidermis. HHV6 infection in the posterior pituitary was confirmed on autopsy, as was infection of the hippocampus, but not of the hypothalamus. This is the first case report of central diabetes insipidus caused by an HHV6 posterior pituitary infection demonstrated on a pathological examination.<br>
収録刊行物
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- Internal Medicine
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Internal Medicine 52 (10), 1107-1110, 2013
一般社団法人 日本内科学会