Clinicopathological Study on Endocrine Cell Micronests Associated with Early Gastric Cancer
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- Suzuki Kenjiro
- Department of Gastroenterology, Sendai City Medical Center, Japan
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- Noda Yutaka
- Department of Gastroenterology, Sendai City Medical Center, Japan
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- Fujita Naotaka
- Department of Gastroenterology, Sendai City Medical Center, Japan
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- Hirasawa Dai
- Department of Gastroenterology, Sendai City Medical Center, Japan
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- Obana Takashi
- Department of Gastroenterology, Sendai City Medical Center, Japan
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- Sugawara Toshiki
- Department of Gastroenterology, Sendai City Medical Center, Japan
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- Ohira Tetsuya
- Department of Gastroenterology, Sendai City Medical Center, Japan
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- Harada Yoshihiro
- Department of Gastroenterology, Sendai City Medical Center, Japan
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- Maeda Yuki
- Department of Gastroenterology, Sendai City Medical Center, Japan
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- Koike Yoshiki
- Department of Gastroenterology, Sendai City Medical Center, Japan
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- Yamagata Taku
- Department of Gastroenterology, Sendai City Medical Center, Japan
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- Kusaka Jun
- Department of Gastroenterology, Sendai City Medical Center, Japan
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- Tanaka Megumi
- Department of Gastroenterology, Sendai City Medical Center, Japan
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- Sawai Takashi
- Department of Pathology, Iwate Medical University, Japan
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- Kurose Akira
- Department of Pathology, Hirosaki University, Japan
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抄録
Objective The purpose of this study was to review cases of early gastric cancer associated with Endocrine cell micronests (ECM) and investigate the incidence and characteristics of these lesions.<br> Methods A total of 482 patients who had undergone endoscopic or surgical resection for gastric epithelial neoplasms from April 2008 to March 2010 were enrolled in this study. After detection of ECM in the lamina propria mucosa by histological examination of the resected specimens with hematoxilin-eosin staining, immunostaining was also performed. Clinical manifestation and endoscopic findings, as well as histological findings, were examined.<br> Results Among the 482 patients, 5 (1.0%) had ECM. The histological type of gastric epithelial cancers associated with ECM was tubular adenocarcinoma and carcinoma in situ (Tis) in the WHO classification in all 5 cases. ECM were round to oval or trabecular and located within the area of the early gastric cancer in all the 5 cases. The background gastric mucosa was Type A gastritis in 2 patients and ordinary atrophic gastritis in 2 patients. In the other case, it was difficult to determine the type of gastritis.<br> Conclusion ECM developed not only from the background of Type A gastritis but also from ordinary atrophic gastritis. ECM coexistent with gastric cancer were present in 1.0% of resectable gastric epithelial neoplasms.<br>
収録刊行物
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- Internal Medicine
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Internal Medicine 52 (12), 1311-1316, 2013
一般社団法人 日本内科学会
