Two Cases of Acute Erythroid Leukemia Presenting with Marked Macrocytic Anemia, Reticulocytosis and Hemolysis

  • Ota Seisuke
    Department of Internal Medicine, Himeji St. Mary's Hospital, Japan Department of Respiratory Internal Medicine, Himeji St. Mary's Hospital, Japan
  • Kasahara Akinori
    Department of Internal Medicine, Himeji St. Mary's Hospital, Japan
  • Mizuno Shoma
    Department of Respiratory Internal Medicine, Himeji St. Mary's Hospital, Japan
  • Uchikoga Osamu
    Department of Internal Medicine, Himeji St. Mary's Hospital, Japan
  • Kuroda Momoko
    Department of Internal Medicine, Himeji St. Mary's Hospital, Japan
  • Miyoshi Haruka
    Department of Internal Medicine, Himeji St. Mary's Hospital, Japan
  • Shiomi Kohei
    Department of Internal Medicine, Himeji St. Mary's Hospital, Japan
  • Umena Sachio
    Department of Internal Medicine, Himeji St. Mary's Hospital, Japan
  • Noguchi Toshio
    Department of Internal Medicine, Himeji St. Mary's Hospital, Japan
  • Kishimoto Nobuyasu
    Department of Respiratory Internal Medicine, Himeji St. Mary's Hospital, Japan
  • Matsumura Tadashi
    Department of Internal Medicine, Himeji St. Mary's Hospital, Japan

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Case 1. The laboratory findings of a hematological analysis of a 53-year-old woman with palpitations and dyspnea revealed the following: red blood cell (RBC) count: 9.4×105 /μL with 60.0‰ reticulocytes; Hb: 3.7 g/dL; mean corpuscular volume (MCV): 124.5 fL; white blood cell (WBC) count: 2,800 /μL with 10.0% myeloblasts. Case 2. Similarly, a 42-year-old man with dizziness had a RBC count of 1.63×106 /μL with 24.0% reticulocytes, an Hb level of 6.0 g/dL, an MCV of 120.2 fL and a WBC count of 3,100 /μL with 4.0% myeloblasts. Bone marrow aspirates in both patients confirmed a diagnosis of acute erythroid leukemia (AEL), which can present as marked macrocytic anemia with an MCV in excess of 120 fL and hemolysis.<br>

収録刊行物

  • Internal Medicine

    Internal Medicine 52 (13), 1509-1512, 2013

    一般社団法人 日本内科学会

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