Double-Hit Lymphoma Demonstrating t(6;14;18)(p25;q32;q21), Suggesting Two Independent Dual-Hit Translocations, MYC/BCL-2 and IRF4/BCL-2
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- Tabata Rie
- Department of Internal Medicine
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- Yasumizu Ryoji
- Department of Pathology, Hyogo Prefectural Tsukaguchi Hospital
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- Tabata Chiharu
- Department of Internal Medicine, Division of Respiratory Medicine, Hyogo College of Medicine
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- Kojima Masaru
- Department of Anatomic and Diagnostic Pathology, Dokkyo Medical University School of Medicine
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Here, we report a rare case of double-hit lymphoma, demonstrating t(6;14;18)(p25;q32;q21), suggesting two independent dual-translocations, c-MYC/BCL-2 and IRF4/BCL-2. The present case had a rare abnormal chromosome, t(6;14;18)(p25;q32;q21), independently, in addition to known dual-hit chromosomal abnormalities, t(14;18)(q32;q21) and t(8;22)(q24;q11.2). Lymph node was characterized by a follicular and diffuse growth pattern with variously sized neoplastic follicles. The intrafollicular area was composed of centrocytes with a few centroblasts and the interfollicular area was occupied by uniformly spread medium- to large-sized lymphocytes. CD23 immunostaining demonstrated a disrupted follicular dendritic cell meshwork. The intrafollicular tumor cells had a germinal center phenotype with the expression of surface IgM, CD10, Bcl-2, Bcl-6, and MUM1/IRF4. However, the interfollicular larger cells showed plasmacytic differentiation with diminished CD20, Bcl-2, Bcl-6, and positive intracytoplasmic IgM, and co-expression of MUM1/IRF4 and CD138 with increased Ki-67-positive cells (> 90%). MUM1/IRF4 has been found to induce c-MYC expression, and in turn, MYC transactivates MUM1/IRF4, creating a positive autoregulatory feedback loop. On the other hand, MUM1/IRF4 functions as a tumor suppressor in c-MYC-induced B-cell leukemia. The present rare case arouses interest in view of the possible “dual” activation of both c-MYC and MUM1/IRF4 through two independent dual-translocations, c-MYC/BCL-2 and IRF4/BCL-2. [J Clin Exp Hematop 53(2) : 141-150, 2013]
収録刊行物
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- Journal of Clinical and Experimental Hematopathology
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Journal of Clinical and Experimental Hematopathology 53 (2), 141-150, 2013
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詳細情報 詳細情報について
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- CRID
- 1390001204705174656
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- NII論文ID
- 10031194236
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- NII書誌ID
- AA11556796
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- COI
- 1:STN:280:DC%2BC3sbksFChsw%3D%3D
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- ISSN
- 18809952
- 13464280
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- PubMed
- 23995111
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可