The Effect of Different Amounts of Calcium Intake on Bone Metabolism and Arterial Calcification in Ovariectomized Rats

DOI Web Site PubMed 被引用文献5件 参考文献41件
  • AGATA Umon
    Institute of Health and Sport Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba
  • PARK Jong-Hoon
    Division of Regenerative Medical Engineering, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo
  • HATTORI Satoshi
    Institute of Health and Sport Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba
  • IIMURA Yuki
    Institute of Health and Sport Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba
  • EZAWA Ikuko
    Japan Women's University
  • AKIMOTO Takayuki
    Division of Regenerative Medical Engineering, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo
  • OMI Naomi
    Health, Physical Education and Sport Sciences, University of Tsukuba Institute of Health and Sport Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba

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Low calcium (Ca) intake is the one of risk factors for both bone loss and medial elastocalcinosis in an estrogen deficiency state. To examine the effect of different amounts of Ca intake on the relationship between bone mass alteration and medial elastocalcinosis, 6-wk-old female SD rats were randomized into ovariectomized (OVX) control or OVX treated with vitamin D3 plus nicotine injection (VDN) groups. The OVX treated with VDN group was then divided into 5 groups depending on the different Ca content in their diet, 0.01%, 0.1%, 0.6%, 1.2%, and 2.4% Ca intakes. After 8 wk of experimentation, the low Ca intake groups of 0.01% and 0.1% showed a low bone mineral density (BMD) and bone properties significantly different from those of the other groups, whereas the high Ca intake groups of 1.2% and 2.4% showed no difference compared with the OVX control. Only in the 0.01% Ca intake group, a significantly higher Ca content in the thoracic artery was found compared with that of the OVX control. Arterial tissues of the 0.01% Ca intake group showed an increase of bone-specific alkaline phosphatase (BAP) activity, a marker of bone mineralization, associated with arterial Ca content. However, the high Ca intake did not affect arterial Ca content nor arterial BAP activity. These results suggested that a low Ca intake during periods of rapid bone loss caused by estrogen deficiency might be one possible cause for the complication of both bone loss and medial elastocalcinosis.

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