High Incidence of Lipid Deposition in the Liver of Rats Fed a Diet Supplemented with Branched-Chain Amino Acids under Vitamin B₆ Deficiency

• KAIMOTO Tae

  Department of Living Science, Shikoku University

• SHIBUYA Mayumi

  Department of Living Science, Shikoku University

• NISHIKAWA Kazutaka

  Faculty of Health and Living Sciences, Graduate School of Education, Naruto University of Education

• MAEDA Hideo

  Faculty of Health and Living Sciences, Graduate School of Education, Naruto University of Education

書誌事項

タイトル別名

• High Incidence of Lipid Deposition in the Liver of Rats Fed a Diet Supplemented with Branched-Chain Amino Acids under Vitamin B₆ Deficiency

抄録

Male Wistar rats were fed four diets composed of purified 20% vitamin-free casein diet with (+) or without (−) vitamin B₆ (7.0 mg of pyridoxine HCl/kg of diet) and with (+) or without (−) branched-chain amino acids (BCAAs) of valine, leucine, and isoleucine (4.75%): B₆(+)BCAA(−); B₆(+)BCAA(+); B₆(−)BCAA(−); and B₆(−)BCAA(+) for 21 d. Among rats fed the B₆(−)BCAA(+) diet, about a half showed lipid deposition in the liver. On the other hand, serum triacylglycerol levels in the B₆(−)BCAA(+) group tended to be decreased. Hepatic triacylglycerol and cholesterol levels tended to increase in the B₆(−)BCAA(+) group compared with the other three groups. Serum apolipoprotein B and apolipoprotein E (apo E) levels in the B₆(−)BCAA(+) group were the lowest among the three groups. In contrast, hepatic apo E levels in the B₆(−)BCAA(+) group were the highest among the three groups. High-performance liquid chromatography of pooled serum of rats with lipid deposits revealed that triacylglycerol and cholesterol levels in very low-density lipoprotein (VLDL) were decreased compared with other diet groups. These results strongly suggest that one of the mechanisms of lipid deposition in rats fed a B₆(−)BCAA(+) diet is due to impaired secretion of VLDL.

収録刊行物

• Ｊｏｕｒｎａｌ　ｏｆ　Ｎｕｔｒｉｔｉｏｎａｌ　Ｓｃｉｅｎｃｅ　ａｎｄ　Ｖｉｔａｍｉｎｏｌｏｇｙ

  Ｊｏｕｒｎａｌ　ｏｆ　Ｎｕｔｒｉｔｉｏｎａｌ　Ｓｃｉｅｎｃｅ　ａｎｄ　Ｖｉｔａｍｉｎｏｌｏｇｙ 59 (1), 73-78, 2013

  一般財団法人 学会誌刊行センター

キーワード

• vitamin B₆ deficiency
• branched-chain amino acid
• lipid deposition
• triacylglycerol
• very low-density lipoprotein

詳細情報

• CRID: 1390001206325441920
• NII論文ID: 130003368152
• NII論文ID: 40019602860
• NII書誌ID: AA00703822
• DOI: 10.3177/jnsv.59.73
• COI: 1:CAS:528:DC%2BC3sXktlels7k%3D
• ISSN: 18817742
• ISSN: 03014800
• NDL書誌ID: 024316103
• PubMed: 23535543
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I024316103
• Web Site: https://search.jamas.or.jp/link/ui/2013276419
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可