-
- Fumio Mizutani
- Graduate School of Material Science, University of Hyogo
書誌事項
- タイトル別名
-
- Award Review Article, 2012 Shikata International Medal : Development of Highly-sensitive Electrochemical Biosensors
この論文をさがす
抄録
This article describes the development of biosensors with electrochemically-amplified responses. In general, chemical amplification involves a reaction sequence for a substrate to generate a relatively large amount of the product. Thus a trace concentration of analyte can be caused to yield orders of magnitude higher product concentration which may be more easily be measured than the analyte itself. For electrochemical biosensors that detect biochemical reactions on the electrode surfaces, chemical amplification procedures suitable for concentrating the electroactive species near the electrode/test solution interface should be utilized to enhance the sensor response effectively. Thus the use of combination of bio-electrochemical processes such as catalytic reaction to regenerate electroactive species and adsorptive stripping procedure to accumulate electroactive species on electrode surfaces can be useful for realizing highly-sensitive biosensors. Actually, immunoassay protocol combined with such electrochemical amplification techniques has enabled us to determine biomarkers with picomolar-levels. Recently we have successfully applied particle manipulation based on dielectrophoresis to develop rapid and separation-free immunosensing systems. The union of highly-sensitive electrochemical detection and dielectrophoretic particle manipulation (or accumulation) would provide biosensor systems suitable for the purpose of the point-of-care testing of biomarkers.
収録刊行物
-
- Review of Polarography
-
Review of Polarography 59 (1), 5-11, 2013
日本ポーラログラフ学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390001206572205056
-
- NII論文ID
- 10031175894
-
- NII書誌ID
- AA00817694
-
- ISSN
- 18847692
- 00346691
-
- NDL書誌ID
- 024782267
-
- 本文言語コード
- ja
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可