多段階カスケード反応を駆使するケミカルバイオロジー研究

• 山口 渉

  Interdisciplinary Graduate School of Science and Engineering, Tokyo Institute of Technology

書誌事項

タイトル別名

• Natural Product-inspired Cascade Synthesis for Chemical Biology

抄録

The development of a highly efficient cascade reaction sequence that rapidly proceeds via 12 consecutive chemical transformations in one pot has been described. This cascade reaction includes nine different chemical reactions and two opposing types of organocatalysis (Brønsted acid and phosphine catalysis) , and terminates in the formation of tetracyclic tetrahydroindolo[2,3-a]quinolizines, which resemble the core scaffold of numerous polycyclic indole alkaloids. By the biological investigation of the corresponding focused compound collections, two highly active compounds were discovered. In addition, cellular targets of the compounds were identified using fluorescent probe.

収録刊行物

• 有機合成化学協会誌

  有機合成化学協会誌 71 (3), 247-248, 2013

  公益社団法人 有機合成化学協会

キーワード

• Organic Chemistry

詳細情報

• CRID: 1390282680316444928
• NII論文ID: 10031157231
• NII書誌ID: AN0024521X
• DOI: 10.5059/yukigoseikyokaishi.71.247
• COI: 1:CAS:528:DC%2BC3sXkvVKgs7g%3D
• ISSN: 18836526
• ISSN: 00379980
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可