2歳未満の急性中耳炎の病態とトスフロキサシンの有効性

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タイトル別名
  • Clinical Characteristics of Acute Otitis Media in Children under the Age of 2 Years and the Efficacy of Tosufloxacin
  • 薬物 2歳未満の急性中耳炎の病態とトスフロキサシンの有効性
  • ヤクブツ 2サイ ミマン ノ キュウセイ チュウジエン ノ ビョウタイ ト トスフロキサシン ノ ユウコウセイ

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Children under the age of 2 years are in a functionally and immunologically immature state and are likely to have a refractory course when diagnosed with acute otitis media (AOM). To clarify the clinical characteristics of AOM in children under 2 years of age (AOM<2), the clinical backgrounds and bacterial pathogens were compared between AOM<2 and AOM in children aged 2 years or older (AOM≧2). Furthermore, the clinical efficacy of treatment with tosufloxacin (tosufloxacin tosilate hydrate, TFLX) on acute otitis media was evaluated in these two age groups.<br> The AOM<2 group had a higher incidence of recurrent and prolonged infections over 3 weeks compared with the AOM≧2 group. In the AOM<2 group, Haemophilus influenzae and Streptococcus pneumoniae, the 2 major pathogenic bacteria, were responsible for 66.7% and 25.6% of the cases, respectively, while in the AOM≧2 group, Haemophilus influenzae and Streptococcus pneumoniae were responsible for 41.1% and 70.5% of the cases, respectively. More than 90% of the isolates were antimicrobial-resistant strains, i.e., β-lactamase non-producing ampicillin resistant Haemophilus influenzae (BLNAR) or penicillin-resistant Streptococcus pneumoniae (PRSP).<br> The present study showed that TFLX was highly effective for the treatment of acute otitis media in both age groups.<br> Based on these results, AOM in patients who are under 2 years of age is likely to be more refractory and to be frequently caused by BLNAR and PRSP. We confirmed that TFLX is effective in patients with a recurrent and prolonged course and should be the drug of choice for children with pretreated and refractory AOM.<br>

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