Evaluation of a Newly Developed Rapid Stool Antigen Test Using an Immunochromatographic Assay To Detect Helicobacter pylori
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- Jekarl Dong Wook
- Department of Laboratory Medicine, The Catholic University of Korea
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- An Yeon Ju
- Department of Laboratory Medicine, The Catholic University of Korea
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- Lee Seungok
- Department of Laboratory Medicine, The Catholic University of Korea
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- Lee Jehoon
- Department of Laboratory Medicine, The Catholic University of Korea
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- Kim Yonggoo
- Department of Laboratory Medicine, The Catholic University of Korea
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- Park Yeon-Joon
- Department of Laboratory Medicine, The Catholic University of Korea
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- Kim Tae Jung
- Department of Pathology, The Catholic University of Korea
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- Kim Jin Il
- Department of Internal Medicine, Division of Gastroenterology, The Catholic University of Korea
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- Park Soo-Heon
- Department of Internal Medicine, Division of Gastroenterology, The Catholic University of Korea
書誌事項
- タイトル別名
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- Evaluation of a Newly Developed Rapid Stool Antigen Test Using an Immunochromatographic Assay To Detect <i>Helicobacter pylori</i>
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抄録
The ASAN Easy Test H. pylori is a newly developed rapid test for Helicobacter pylori that uses a stool antigen immunochromatographic assay (S-ICT). The aim of this study was to evaluate this kit for the diagnosis of H. pylori under various histological conditions. We enrolled 266 consecutive patients undergoing a routine health checkup and endoscopy with biopsy. H. pylori infection was confirmed if at least 2 out of the 3 following tests were positive: histology, real-time polymerase chain reaction (PCR), and the stool antigen test by enzyme immunoassay (S-EIA). Histological examination was performed using hematoxylin-eosin and silver staining. Real-time PCR was performed with a probe for the UreA gene as described previously. The S-EIA and the evaluated kit were used according to the manufacturers' instructions. Of the 266 patients, 209 were eligible for participation. The evaluation results were as follows: sensitivity, 84.5%; specificity, 96.2%; positive-predictive value, 95.6%; negative-predictive value, 86.4%; and accuracy, 90.4%. The performance of the kit was unaffected by histological findings such as atrophic gastritis, ulcers, and intestinal metaplasia. The newly developed S-ICT assay is a non-invasive rapid test for the diagnosis of H. pylori that exhibits good performance in routine health checkup patients.
収録刊行物
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- Japanese Journal of Infectious Diseases
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Japanese Journal of Infectious Diseases 66 (1), 60-64, 2013
国立感染症研究所 Japanese Journal of Infectious Diseases 編集委員会
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詳細情報 詳細情報について
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- CRID
- 1390282681217800832
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- NII論文ID
- 130003381644
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- NII書誌ID
- AA1132885X
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- ISSN
- 18842836
- 13446304
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- NDL書誌ID
- 024217316
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- PubMed
- 23429088
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可