Calysolins Ⅴ-Ⅸ, Resin Glycosides from Calystegia soldanella and Their Antiviral Activity toward Herpes
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- Ono Masateru
- School of Agriculture, Tokai University
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- Takigawa Ayako
- School of Agriculture, Tokai University
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- Kanemaru Yukiyo
- School of Agriculture, Tokai University
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- Kawakami Gen
- School of Agriculture, Tokai University
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- Kabata Kiyotaka
- School of Agriculture, Tokai University
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- Okawa Masafumi
- Faculty of Pharmaceutical Sciences, Fukuoka University
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- Kinjo Junei
- Faculty of Pharmaceutical Sciences, Fukuoka University
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- Yokomizo Kazumi
- Faculty of Pharmaceutical Sciences, Sojo University
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- Yoshimitsu Hitoshi
- Faculty of Pharmaceutical Sciences, Sojo University
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- Nohara Toshihiro
- Faculty of Pharmaceutical Sciences, Sojo University
書誌事項
- タイトル別名
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- Calysolins V–IX, Resin Glycosides from <i>Calystegia soldanella</i> and Their Antiviral Activity toward Herpes
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抄録
Five new resin glycosides having macrolactone structures (jalapins), named calysolins V–IX (1–5), were isolated from the leaves, stems, and roots of Calystegia soldanella ROEM. et SCHULT. (Convolvulaceae). Their structures were determined on the basis of spectroscopic data as well as chemical evidence. The isolated compounds could be classified into two macrolactone types—one having a 22-membered ring (1–4) and the other with a 27-membered ring (5). The sugar moieties of 1–5 were found to exist in partially acylated forms comprising 2S-methylbutyric acid and tiglic acid. Compounds 4 and 5 are the first representatives of the calysolic acid C as the component glycosidic acid. Additionally, the antiviral activity of 1–5, together with calysolins I–IV and soldanelline B, which are previously isolated jalapins from this plant, toward herpes simplex virus type 1 was evaluated. All the compounds showed antiviral activity.
収録刊行物
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- CHEMICAL & PHARMACEUTICAL BULLETIN
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CHEMICAL & PHARMACEUTICAL BULLETIN 62 (1), 97-105, 2014
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679153794304
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- NII論文ID
- 130003381808
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- NII書誌ID
- AA00602100
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- COI
- 1:STN:280:DC%2BC2czitFKntg%3D%3D
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- ISSN
- 13475223
- 00092363
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- NDL書誌ID
- 025136307
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- PubMed
- 24390499
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可