Anti-Inflammatory Activities of Methanol Extract of Mastixia arborea C.B. Clarke as to Mouse Macrophage and Paw Edema

DOI Web Site Web Site PubMed 参考文献15件
  • KIM Hui-Seong
    Biomolecular Science, University of Science and Technology Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology
  • KWON Ok-Kyoung
    Department of Toxicology, College of Pharmacy, Chungnam National University Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology
  • PARK Ji-Won
    Department of Biotechnology, Korea University Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology
  • JEONG Hye Gwang
    Department of Toxicology, College of Pharmacy, Chungnam National University
  • OH Sei-Ryang
    Biomolecular Science, University of Science and Technology Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology
  • LEE Hyeong-Kyu
    Biomolecular Science, University of Science and Technology Targeted Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology
  • BACH Tran The
    Department of Botany, Institute of Ecology and Biological Resources, Vietnam Academy of Science and Technology
  • HAI Do Van
    Department of Botany, Institute of Ecology and Biological Resources, Vietnam Academy of Science and Technology
  • AHN Kyung-Seop
    Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology

書誌事項

タイトル別名
  • Anti-Inflammatory Activities of Methanol Extract of <i>Mastixia arborea</i> C.B. Clarke as to Mouse Macrophage and Paw Edema

この論文をさがす

抄録

The biological activity of Mastixia arborea (MA) relates to inflammation, but the underlying mechanisms are largely unknown. We confirmed the anti-inflammatory effects of a methanol extract of MA extract on lipopolysaccharide (LPS)-stimulated RAW264.7 mouse macrophage cells and carrageenan-induced mice paw edema. The MA extract significantly inhibited nitric oxide (NO), prostaglandin E2 (PGE2), interleukin-1β (IL-1β), and IL-6 production in LPS-stimulated RAW264.7 cells. In vitro expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) was suppressed by the extract. The extract attenuated acute inflammatory responses in carrageenan-induced mice paw edema. A mechanism study indicated that translocation of the NF-κB (p65) subunit into the nucleus and phosphorylation of ERK and JNK were inhibited by the extract. These results indicate that the extract is an effective suppressor of the inflammatory response, blocking the phosphorylation of ERK and JNK and the translocation of NF-κB in macrophages, thereby producing an anti-inflammatory effect in vivo.

収録刊行物

参考文献 (15)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ