Acute-Phase Glucose Fluctuation Is Negatively Correlated With Myocardial Salvage After Acute Myocardial Infarction : Involvement of Monocyte Subsets

• Teraguchi Ikuko

  Departments of Cardiovascular Medicine, Wakayama Medical University

• Imanishi Toshio

  Departments of Cardiovascular Medicine, Wakayama Medical University

• Ozaki Yuichi

  Departments of Cardiovascular Medicine, Wakayama Medical University

• Tanimoto Takashi

  Departments of Cardiovascular Medicine, Wakayama Medical University

• Ueyama Minoru

  Clinical Laboratory Medicine, Wakayama Medical University

• Orii Makoto

  Departments of Cardiovascular Medicine, Wakayama Medical University

• Shiono Yasutsugu

  Departments of Cardiovascular Medicine, Wakayama Medical University

• Shimamura Kunihiro

  Departments of Cardiovascular Medicine, Wakayama Medical University

• Ishibashi Kohei

  Departments of Cardiovascular Medicine, Wakayama Medical University

• Yamano Takashi

  Departments of Cardiovascular Medicine, Wakayama Medical University

• Ino Yasushi

  Departments of Cardiovascular Medicine, Wakayama Medical University

• Yamaguchi Tomoyuki

  Departments of Cardiovascular Medicine, Wakayama Medical University

• Hirata Kumiko

  Departments of Cardiovascular Medicine, Wakayama Medical University

• Kubo Takashi

  Departments of Cardiovascular Medicine, Wakayama Medical University

• Sanke Tokio

  Institute for Diabetes, Fuchu Hospital

• Akasaka Takashi

  Departments of Cardiovascular Medicine, Wakayama Medical University

書誌事項

タイトル別名

• Acute-Phase Glucose Fluctuation Is Negatively Correlated With Myocardial Salvage After Acute Myocardial Infarction
• – Involvement of Monocyte Subsets –

抄録

Background: It remains unclear whether glycemic fluctuation immediately after acute myocardial infarction (AMI) can affect myocardial damage. This study investigated the impact of glucose fluctuation on myocardial salvage following successful recanalization of primary AMI. Methods and Results: A total of 36 consecutive patients with AMI were studied. Glycemic variability, as indicated by the mean amplitude of glycemic excursion (MAGE), was measured on a continuous glucose monitoring system. Three subsets (CD14⁺CD16⁻, CD14⁺⁺CD16⁺ and CD14⁺⁻CD16⁺) were measured on flow cytometry 1, 2, 3, 4 and 5 days after AMI onset. A 2-h oral glucose test was performed in 23 patients who had no previous diagnosis of diabetes and/or glycated hemoglobin <6.5%, after the onset of AMI at 2 weeks. Plasma active glucagon-like peptide (GLP)-1 level was measured in each sample. The extent of myocardial salvage 7 days after AMI was evaluated on cardiovascular magnetic resonance imaging. MAGE and the peak CD14⁺CD16⁻ monocyte level were significantly negatively correlated with myocardial salvage index (MSI). MAGE was significantly correlated with peak CD14⁺CD16⁻ monocyte level. Of interest, plasma GLP-1 level was significantly positively correlated with MSI and significantly negatively correlated with MAGE. Conclusions: Glucose fluctuations during the acute phase of AMI affect MSI, indicating that manipulation of glucose variability from peak to nadir might be a potential therapeutic target for salvaging ischemic damage.  (Circ J 2014; 78: 170–179)<br>

収録刊行物

• Circulation Journal

  Circulation Journal 78 (1), 170-179, 2014

  一般社団法人 日本循環器学会

キーワード

• Acute myocardial infarction
• Glucagon-like peptide-1
• Glucose fluctuation
• Monocyte
• Myocardial salvage

詳細情報

• CRID: 1390001205108903936
• NII論文ID: 130003382180
• NII書誌ID: AA11591968
• DOI: 10.1253/circj.cj-13-0723
• COI: 1:CAS:528:DC%2BC2cXjt1yrsrc%3D
• ISSN: 13474820
• ISSN: 13469843
• NDL書誌ID: 025112597
• PubMed: 24189501
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I025112597
• Web Site: https://www.jstage.jst.go.jp/article/circj/78/1/78_CJ-13-0723/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2014247991
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
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