Soluble ST2 and N-terminal pro-Brain Natriuretic Peptide Combination : Useful Biomarker for Predicting Outcome of Childhood Pulmonary Arterial Hypertension

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  • Chida Ayako
    Departments of Pediatrics, National Defense Medical College Department of Pediatric Cardiology, Tokyo Women’s Medical University
  • Sato Hiroki
    Preventive Medicine and Public Health, National Defense Medical College
  • Shintani Masaki
    Department of Pediatric Cardiology, Tokyo Women’s Medical University
  • Nakayama Tomotaka
    Department of Pediatrics, Toho University Medical Center, Omori Hospital
  • Kawamura Yoichi
    Departments of Pediatrics, National Defense Medical College
  • Furutani Yoshiyuki
    Department of Pediatric Cardiology, Tokyo Women’s Medical University
  • Inai Kei
    Department of Pediatric Cardiology, Tokyo Women’s Medical University
  • Saji Tsutomu
    Department of Pediatrics, Toho University Medical Center, Omori Hospital
  • Matsuoka Rumiko
    International Research and Educational Institute for Integrated Medical Sciences (IREIIMS), Tokyo Women’s Medical University International Center for Molecular, Cellular and Immunological Research (IMCIR), Tokyo Women’s Medical University Department of Pediatrics, Faculty of Medicine, Toho University
  • Nonoyama Shigeaki
    Departments of Pediatrics, National Defense Medical College
  • Nakanishi Toshio
    Department of Pediatric Cardiology, Tokyo Women’s Medical University

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タイトル別名
  • Soluble ST2 and N-terminal pro-Brain Natriuretic Peptide Combination
  • – Useful Biomarker for Predicting Outcome of Childhood Pulmonary Arterial Hypertension –

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Background: Some potential biomarkers have been reported recently in patients with pulmonary arterial hypertension (PAH), but the most clinically useful among these potential biomarkers, especially in childhood PAH, has not been identified. Therefore, this study investigated which biomarker is useful in assessing severity of and patient prognosis in childhood idiopathic PAH (IPAH)/heritable PAH (HPAH). Methods and Results: Fifty-nine patients who were younger than 16 years at onset of IPAH/HPAH were selected. The following 10 biomarker candidates were quantified: high-sensitivity troponin T, human heart fatty acid-binding protein, N-terminal pro-brain natriuretic peptide (NT-proBNP), pentraxin-3, soluble ST2 (sST2), angiopoietin-2 (Ang-2), matrix metalloproteinase 2, tenascin C, endostatin (ES), and thymidine kinase. Functional characteristics and clinical outcomes were analyzed retrospectively. NT-proBNP, sST2, Ang-2, and ES correlated well with New York Heart Association class. On area under the receiver operating characteristic curve analysis, sST2 had a significantly good relationship with prognosis. On Kaplan-Meier curve and univariate Cox regression analyses, elevated sST2 and NT-proBNP level predicted poor outcome of the present patients with childhood IPAH/HPAH. Furthermore, patients with elevated sST2 had significantly worse prognosis among those with high NT-proBNP. Conclusions: The sST2 and NT-proBNP combination is a useful biomarker to predict clinical condition and outcome in patients with childhood IPAH/HPAH.  (Circ J 2014; 78: 436–442)<br>

収録刊行物

  • Circulation Journal

    Circulation Journal 78 (2), 436-442, 2014

    一般社団法人 日本循環器学会

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