非等温環境でのチアミン硝化物の安定性に及ぼす熱伝導と包装容器の影響

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  • 中村 亨
    星薬科大学薬学部薬剤学教室 大正製薬株式会社セルフメディケーション開発研究所内服液剤開発研究室
  • 山地 貴之
    大正製薬株式会社セルフメディケーション開発研究所内服液剤開発研究室
  • 高山 幸三
    星薬科大学薬学部薬剤学教室

書誌事項

タイトル別名
  • Effect of Heat Transfer in the Packages on the Stability of Thiamine Nitrate under Uncontrolled Temperature Conditions
  • ヒトウオン カンキョウ デ ノ チアミンショウカブツ ノ アンテイセイ ニ オヨボス ネツ デンドウ ト ホウソウ ヨウキ ノ エイキョウ

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抄録

  To accurately predict the stability of thiamine nitrate as a model drug in pharmaceutical products under uncontrolled temperature conditions, the average reaction rate constant was determined, taking into account the heat transfer from the atmosphere to the product. The stability tests of thiamine nitrate in the three packages with different heat transfers were performed under non-isothermal conditions. The stability data observed were compared with the predictions based on a newly developed method, showing that the stability was well predicted by the method involving the heat transfer. By contrast, there were some deviations observed from the predicted data, without considering heat transfer in the packages with low heat transfer. The above-mentioned result clearly shows that heat transfer should be considered to ensure accurate prediction of the stability of commercial pharmaceutical products under non-isothermal atmospheres.<br>

収録刊行物

  • 薬学雑誌

    薬学雑誌 133 (12), 1411-1415, 2013-12-01

    公益社団法人 日本薬学会

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