In Vitro Susceptibility of Malassezia pachydermatis Isolates from Canine Skin with Atopic Dermatitis to Ketoconazole and Itraconazole in East Asia

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  • WATANABE Shion
    Department of Pathobiology, Nihon University School of Veterinary Medicine, 1866 Kameino, Fujisawa, Kanagawa 252–0880, Japan
  • KOIKE Anna
    Department of Pathobiology, Nihon University School of Veterinary Medicine, 1866 Kameino, Fujisawa, Kanagawa 252–0880, Japan
  • KANO Rui
    Department of Pathobiology, Nihon University School of Veterinary Medicine, 1866 Kameino, Fujisawa, Kanagawa 252–0880, Japan
  • NAGATA Masahiko
    ASC Dermatology Service, 1–3–2 Higashicho, Jindaiji, Chofu, Tokyo 182–0012, Japan
  • CHEN Charles
    Asian Veterinary Specialist Referral Center, 1st Floor, No. 109, Section 4, XinYi Road, Taipei 106, Taiwan
  • HWANG Cheol-Yong
    Department of Internal Medicine (Dermatology), College of Veterinary Medicine, Seoul National University, Seoul 151–742, Korea
  • HASEGAWA Atsuhiko
    Teikyo University Institute of Medical Mycology, 359 Otsuka, Hachioji, Tokyo 192–0395, Japan
  • KAMATA Hiroshi
    Department of Pathobiology, Nihon University School of Veterinary Medicine, 1866 Kameino, Fujisawa, Kanagawa 252–0880, Japan

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タイトル別名
  • <i>In Vitro</i> Susceptibility of <i>Malassezia pachydermatis</i> Isolates from Canine Skin with Atopic Dermatitis to Ketoconazole and Itraconazole in East Asia

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Topical or oral azole antifungals are commonly used in canine atopic dermatitis (AD), as the lipophilic yeast Malassezia pachydermatis exacerbates canine AD. To examine whether canine AD lesions harbor azole-resistant M. pachydermatis isolates in East Asia, we investigated the in vitro susceptibility of M. pachydermatis isolates to ketoconazole (KTZ) and itraconazole (ITZ) obtained from AD lesions of canines in Japan, Korea and Taiwan. The minimum inhibitory concentrations (MICs) of KTZ and ITZ were measured by the E-test using Sabouraud dextrose agar with 0.5% Tween 40. The MICs of KTZ and ITZ for isolates from canines with AD were significantly higher than the MICs for isolates from healthy canines. Our findings suggested that the clinical isolates from canine AD skin lesions were less susceptible to azoles than those from normal canine skin in East Asia.

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