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- Ohira Toko
- Pathology Division, Gotemba Laboratories, BoZo Research Center Inc.
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- Saito Tsubasa
- Pathology Division, Gotemba Laboratories, BoZo Research Center Inc.
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- Ando Ryo
- Pathology Division, Gotemba Laboratories, BoZo Research Center Inc.
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- Tamura Kazutoshi
- Pathology Division, Gotemba Laboratories, BoZo Research Center Inc.
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- Hoshiya Toru
- Pathology Division, Gotemba Laboratories, BoZo Research Center Inc.
この論文をさがす
抄録
Busulfan is an antineoplastic bifunctional alkylating agent. We previously reported the busulfan-induced systemic histopathological changes in fetal rats and the sequence of brain lesions in fetal and infant rats. In the present study, in order to clarify the nature and sequence of busulfan-induced systemic histopathological changes in infant rats, 6-day-old male infant rats were subcutaneously administered 20 mg/kg of busulfan and histopathologically examined at 1, 2, 4, 7 and 14 days after treatment (DAT). As a result, histopathological changes characterized by pyknosis of component cells were observed in the heart, lungs, stomach, intestines, liver, kidneys, testes, epididymides, hematopoietic and lymphoid tissues, dorsal skin and femur as well as in the brain and eyes (data not shown in this paper). Such pyknosis transiently appeared until 7 DAT with prominence at 2 and/or 4 DAT in each tissue, except for the thymus, in which pyknosis peaked at 1 DAT. Most of the pyknotic nuclei were immunohistochemically positive for cleaved caspase-3, indicating that pyknotic cells were apoptotic. Different from the reports of fetal and adult rats, apoptosis was also found in cardiomyocytes and osteoblasts in infant rats.
収録刊行物
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- Journal of Toxicologic Pathology
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Journal of Toxicologic Pathology 27 (1), 25-29, 2014
日本毒性病理学会
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詳細情報 詳細情報について
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- CRID
- 1390001204414194048
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- NII論文ID
- 130003382473
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- NII書誌ID
- AN10232280
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- COI
- 1:STN:280:DC%2BC2cnpsFahtg%3D%3D
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- ISSN
- 1881915X
- 09149198
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- NDL書誌ID
- 025510292
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- PubMed
- 24791064
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可