Establishment of an Invasive Prostate Cancer Model in Transgenic Rats by Intermittent Testosterone Administration
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- Sato Shinya
- Department of Experimental Pathology and Tumor Biology
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- Suzuki Shugo
- Department of Experimental Pathology and Tumor Biology
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- Naiki-Ito Aya
- Department of Experimental Pathology and Tumor Biology
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- Komiya Masami
- Department of Experimental Pathology and Tumor Biology
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- Ne Long
- Department of Experimental Pathology and Tumor Biology
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- Kato Hiroyuki
- Department of Experimental Pathology and Tumor Biology
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- Sagawa Hiroyuki
- Department of Experimental Pathology and Tumor Biology
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- Yamashita Yoriko
- Department of Experimental Pathology and Tumor Biology
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- Shirai Tomoyuki
- Department of Experimental Pathology and Tumor Biology
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- Takahashi Satoru
- Department of Experimental Pathology and Tumor Biology
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抄録
We have established a transgenic rat for adenocarcinoma of the prostate (TRAP) model that features uniform adenocarcinoma development in prostatic lobes at high incidence within a short experimental period. However, no invasive carcinomas with reactive stroma characteristics similar to those in man were observed. We therefore have focused on a new model for invasive carcinoma of the prostate using TRAP rats. In experiment 1, male TRAP rats in groups 1 and 2 were treated with orchiectomy at day 0 of the experiment. Rats in groups 1–3 underwent testosterone propionate (TP) implantation from weeks 1 to 4 and from weeks 6 to 16. Rats in groups 1 and 3 were given 3,2’-dimethyl-4-aminobiphenyl (DMAB) after TP implantation. The rats of group 4 served as controls. In experiment 2, the rats were divided into three groups, none of which received DMAB or orchiectomy, treated with TP continuously or with the treatment withdrawn once or twice. In experiment 1, invasive adenocarcinomas with abundant collagenous stroma were found in the dorsolateral and anterior prostate, some of which showed perineural space invasion at week 16. The number of invasive carcinoma foci was most frequent in group 3. In experiment 2, invasive adenocarcinoma development in the lateral prostates was correlated with the number of TP administration/withdrawal cycles. In conclusion, our newly established rat model for invasive adenocarcinoma of the prostate could serve as a useful preclinical model for evaluating the in vivo efficacy of preventive and therapeutic agents targeting of the tumor microenvironment.
収録刊行物
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- Journal of Toxicologic Pathology
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Journal of Toxicologic Pathology 27 (1), 43-49, 2014
日本毒性病理学会
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詳細情報 詳細情報について
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- CRID
- 1390282679390818944
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- NII論文ID
- 130003382476
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- NII書誌ID
- AN10232280
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- COI
- 1:STN:280:DC%2BC2cnpsFahtA%3D%3D
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- ISSN
- 1881915X
- 09149198
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- NDL書誌ID
- 025510338
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- PubMed
- 24791066
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可