Inhibition of the PI3K/AKT-NF-κB Pathway With Curcumin Enhanced Radiation-Induced Apoptosis in Human Burkitt’s Lymphoma
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- Qiao Qiao
- Department of Radiotherapy, the First Hospital of China Medical University, China
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- Jiang Yuanjun
- Department of Urology, the First Hospital of China Medical University, China
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- Li Guang
- Department of Radiotherapy, the First Hospital of China Medical University, China
書誌事項
- タイトル別名
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- Inhibition of the PI3K/AKT-NF-<i>κ</i>B Pathway With Curcumin Enhanced Radiation-Induced Apoptosis in Human Burkitt’s Lymphoma
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The phosphatidylinositol-3-kinase (PI3K) / protein kinase B (AKT) signal transduction pathway is commonly misregulated in lymphoma and associated with tumorigenesis and enhanced resistance to radiotherapy. Curcumin has been shown to inhibit the PI3K/AKT signal transduction pathway in several tumor models. In this study, we found that curcumin inhibits constitutive and radiation-induced expression of the PI3K/AKT pathway and its downstream regulator nuclear factor kappaB (NF-κB) in human Burkitt’s lymphoma, a high-grade non-Hodgkin’s lymphoma (NHL). We further demonstrated that the blockage of radiation-induced activation of the PI3K/AKT pathway and its downstream regulator NF-κB by either curcumin or specific PI3/AKT inhibitors (LY294002 for PI3K or SH-5 for AKT) enhance apoptosis in three human Burkitt’s lymphoma cell lines (Namalwa, Ramos, and Raji) that were treated with ionizing radiation. However, no synergic effect on radiation-induced apoptosis was found in the cells co-pretreated with curcumin combined with LY294002 or curcumin combined with SH-5. The results from this study suggest that curcumin might play an important role in radiotherapy of high-grade NHL through inhibition of the PI3K/AKT-dependent NF-κB pathway.
収録刊行物
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- Journal of Pharmacological Sciences
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Journal of Pharmacological Sciences 121 (4), 247-256, 2013
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390001205179520256
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- NII論文ID
- 10031171134
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- NII書誌ID
- AA11806667
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- COI
- 1:CAS:528:DC%2BC3sXnt1aisrk%3D
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- ISSN
- 13478648
- 13478613
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- NDL書誌ID
- 024434296
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- PubMed
- 23603894
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 使用不可