Synthesis of Xanthanolides Including New Acylations and Their Synthetic Applications

DOI Web Site 参考文献67件
  • Shindo Mitsuru
    Institute for Materials Chemistry and Engineering, Kyushu University
  • Matsumoto Kenji
    Institute for Materials Chemistry and Engineering, Kyushu University

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Xanthanolides were synthesized with intramolecular acylation of organolithium forming a seven-membered carbocycle and one-pot acylation-Wittig lactonization as key steps. The Cu(II) complex efficiently catalyzed the acylation of thioester in Wittig lactonization under neutral conditions. Using the Cu(II) catalyst, symmetric dithiomalonates were converted into dissymmetric S,O-malonates via selective monoacylation. The key step in this reaction was the thermal formation of an acylketene, the stability of which would contribute to selectivity.

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