Antimicrobial Activity of Pantothenol against Staphylococci Possessing a Prokaryotic Type II Pantothenate Kinase

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  • Chohnan Shigeru
    Department of Bioresource Science, Ibaraki University College of Agriculture Department of Applied Life Science, United Graduate School of Agricultural Science, Tokyo University of Agriculture and Technology
  • Murase Misa
    Department of Bioresource Science, Ibaraki University College of Agriculture
  • Kurikawa Kota
    Department of Bioresource Science, Ibaraki University College of Agriculture
  • Higashi Kodai
    Department of Bioresource Science, Ibaraki University College of Agriculture
  • Ogata Yuta
    Department of Applied Life Science, United Graduate School of Agricultural Science, Tokyo University of Agriculture and Technology

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Pantothenol is a provitamin of pantothenic acid (vitamin B5) that is widely used in healthcare and cosmetic products. This analog of pantothenate has been shown to markedly inhibit the phosphorylation activity of the prokaryotic type II pantothenate kinase of Staphylococcus aureus, which catalyzes the first step of the coenzyme A biosynthetic pathway. Since type II enzymes are found exclusively in staphylococci, pantothenol suppresses the growth of S. aureus, S. epidermidis, and S. saprophyticus, which inhabit the skin of humans. Therefore, the addition of this provitamin to ointment and skincare products may be highly effective in preventing infections by opportunistic pathogens.

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