Protective Effect of Genistein on Lipopolysaccharide/D-Galactosamine-Induced Hepatic Failure in Mice
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- Lin Xing
- Guangxi Medical University
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- Zhang Shijun
- Guangxi Medical University
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- Huang Renbin
- Guangxi Medical University
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- Wei Ling
- Guangxi Medical University
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- Liang Chunhong
- Guangxi Medical University
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- Chen Yongxing
- Guangxi Medical University
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- Lv Shujuan
- Guangxi Medical University
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- Liang Shuang
- The First Affiliated Hospital of Guangxi University of Chinese Medicine
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- Wu Xiaoyan
- The First Affiliated Hospital of Guangxi University of Chinese Medicine
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- Huang Quanfang
- The First Affiliated Hospital of Guangxi University of Chinese Medicine
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This study examined the effect of genistein from Hydrocotyle sibthorpioides on lipopolysaccharide (LPS)/D-galactosamine (D-GalN)-induced acute hepatic failure. Compared to the model control, genistein treatment significantly protected against LPS/D-GalN-induced liver injury, as evidenced by the decrease in serum alanine and aspartate aminotransferases activities and the attenuation of histopathological changes. Furthermore, genistein alleviated the pro-inflammatory cytokines including tumor necrosis factor-alpha (TNF-α) and nitric oxide (NO)/inducible nitric oxide synthase (iNOS) by inhibiting nuclear factor-κB (NF-κB) activity. Genistein attenuated the elevated level of caspases-3, while augmented the expression of Bcl-2. In addition, LPS/D-GalN induced significant increase of heme oxygenase (HO), carbon monoxide and bilirubin levels and these alterations were augmented by genistein treatment. In conclusion, the protective effect of genistein on LPS/D-GalN-induced liver damage was mainly due to its ability to block NF-κB signaling pathway for anti-inflammation response, attenuate hepatocellular apoptosis and increase HO level. These findings suggest that genistein can be considered as a potential agent for preventing acute hepatic failure.
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 37 (4), 625-632, 2014
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001204631270784
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- NII論文ID
- 130003390981
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- NII書誌ID
- AA10885497
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- COI
- 1:STN:280:DC%2BC2cvgt1SmtA%3D%3D
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 025371163
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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