Cerebellar Ataxia Suspected to Be Caused by <i>Oxytropis glabra</i> Poisoning in Western Mongolian Goats
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- TAKEDA Shuji
- Department of Veterinary Pathology, Tottori University, Tottori 680–8553, Japan
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- TANAKA Hiroyuki
- Department of Veterinary Pathology, Tottori University, Tottori 680–8553, Japan
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- SHIMADA Akinori
- Laboratory of Pathology, Azabu University, Sagamihara-shi, Kanagawa 252–5201, Japan
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- MORITA Takehito
- Department of Veterinary Pathology, Tottori University, Tottori 680–8553, Japan
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- ISHIHARA Atsushi
- Department of Agricultural Chemistry, Tottori University, Tottori 680–8553, Japan
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- ADILBISH Altanchimeg
- Institute of Veterinary Medicine, Zaisan 210153, Ulaanbaatar, Mongolia
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- DELGERMAA Bayarmunkh
- Institute of Veterinary Medicine, Zaisan 210153, Ulaanbaatar, Mongolia
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- GUNGAA Oyuntsetseg
- Institute of Veterinary Medicine, Zaisan 210153, Ulaanbaatar, Mongolia
Bibliographic Information
- Other Title
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- Pathology : Cerebellar Ataxia Suspected to Be Caused by Oxytropis glabra Poisoning in Western Mongolian Goats
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Abstract
In the last five years in western Mongolia, a neurological disorder and resultant economic loss have developed in goats, sheep, cattle and horses: association of the disease with ingestion of Oxytropis glabra, a toxic plant, was suggested. Affected goats showed neurological signs, including ataxia, incoordination, hind limb paresis, fine head tremor and nystagmus. Three goats, one with moderate clinical signs and the other two with severe clinical signs, were necropsied and examined to describe and characterize the histologic, immunohistochemical and ultrastructural lesions. Although no gross pathological changes were observed in a variety of organs including the central nervous system of these goats, microscopic examination of the cerebellum demonstrated degenerative changes in all these goats, such as vacuolar changes and loss of Purkinje cells, torpedo formation in the granular layer, increased number of spheroids in the cerebellar medulla, and loss of axons and myelin sheaths of Purkinje cells. The chemical analysis of the dried plant detected 0.02–0.05% (dry weight basis) of swainsonine. This is the first report describing the clinical and pathological findings in Mongolian goats suspected to be affected by O. glabra poisoning.
Journal
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- Journal of Veterinary Medical Science
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Journal of Veterinary Medical Science 76 (6), 839-846, 2014
JAPANESE SOCIETY OF VETERINARY SCIENCE
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Details 詳細情報について
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- CRID
- 1390282681406453248
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- NII Article ID
- 130003391292
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- NII Book ID
- AA10796138
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- COI
- 1:STN:280:DC%2BC2cvot12htA%3D%3D
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- ISSN
- 13477439
- 09167250
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- NDL BIB ID
- 025618024
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- PubMed
- 24572629
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed