Involvement of 5-HT₃ and 5-HT₄ Receptors in the Regulation of Circadian Clock Gene Expression in Mouse Small Intestine
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- Aoki Natsumi
- Laboratory of Physiology and Pharmacology, School of Advanced Science and Engineering, Waseda University, Japan
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- Watanabe Hiroyuki
- Laboratory of Physiology and Pharmacology, School of Advanced Science and Engineering, Waseda University, Japan
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- Okada Kazuya
- Laboratory of Physiology and Pharmacology, School of Advanced Science and Engineering, Waseda University, Japan
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- Aoki Kazuyuki
- Laboratory of Physiology and Pharmacology, School of Advanced Science and Engineering, Waseda University, Japan
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- Imanishi Takuma
- Laboratory of Physiology and Pharmacology, School of Advanced Science and Engineering, Waseda University, Japan
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- Yoshida Daisuke
- Laboratory of Physiology and Pharmacology, School of Advanced Science and Engineering, Waseda University, Japan
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- Ishikawa Ryosuke
- Laboratory of Physiology and Pharmacology, School of Advanced Science and Engineering, Waseda University, Japan
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- Shibata Shigenobu
- Laboratory of Physiology and Pharmacology, School of Advanced Science and Engineering, Waseda University, Japan
書誌事項
- タイトル別名
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- Involvement of 5-HT<sub>3</sub> and 5-HT<sub>4</sub> Receptors in the Regulation of Circadian Clock Gene Expression in Mouse Small Intestine
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抄録
Several lines of evidence suggest that 5-HT receptors play a critical role in the expression of clock genes in the suprachiasmatic nucleus, the main circadian oscillator in hamsters. The contributions of 5-HT-receptor subtypes in the intestine, where they are expressed at high concentrations, are however not yet clarified. The 5-HT synthesis inhibitor, p-chlorophenylalanine, attenuated the daily rhythm of Per1 and Per2 gene expression in the intestine. Injection of 5-HT and agonists of the 5-HT3 and 5-HT4 receptors increased Per1/Per2 expression and decreased Bmal1 expression in a dose-dependent manner. Although treatment with antagonists of 5-HT3 and 5-HT4 alone did not affect clock gene expression, co-injection of these antagonists with 5-HT blocked the 5-HT-induced changes in clock gene expression. Increased tissue levels of 5-HT due to treatment with the antidepressants clomipramine and fluvoxamine did not affect clock gene expression. The present results suggest that the 5-HT system in the small intestine may play a critical role in regulating circadian rhythms through 5-HT3/5-HT4-receptor activation.
収録刊行物
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- Journal of Pharmacological Sciences
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Journal of Pharmacological Sciences 124 (2), 267-275, 2014
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390001205179570816
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- NII論文ID
- 130003391485
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- NII書誌ID
- AA11806667
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- COI
- 1:CAS:528:DC%2BC2cXkt1egtL4%3D
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- ISSN
- 13478648
- 13478613
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- NDL書誌ID
- 025296300
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- PubMed
- 24492464
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可