Rikkunshito, a Kampo Medicine, Ameliorates Post-operative Ileus by Anti-inflammatory Action
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- Endo Mari
- Department of Clinical Research, Oriental Medicine Research Center, Kitasato University, Japan
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- Hori Masatoshi
- Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Japan
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- Ozaki Hiroshi
- Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Japan
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- Oikawa Tetsuro
- Department of Clinical Research, Oriental Medicine Research Center, Kitasato University, Japan
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- Hanawa Toshihiko
- Department of Clinical Research, Oriental Medicine Research Center, Kitasato University, Japan Kitasato University Graduate School, Doctoral Program of Medical Science, Oriental Medicine, Japan
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Abstract
Rikkunshito (RKT), a Kampo (Japanese herbal) medicine, is used as a prokinetic for patients with various diseases including functional dyspepsia. RKT promotes delayed gastric emptying via 5-HT3 receptor blockade. Otherwise, RKT increases ghrelin release via 5-HT2B and 5-HT2C receptor activation. Recent studies revealed that ghrelin and 5-HT3 receptor antagonists have an anti-inflammatory effect. So we hypothesize that RKT may have an anti-inflammatory action in the post-operative ileus. Intestinal manipulation (IM) was applied to the distal ileum of mice. RKT was administered orally 4 times before and after IM. Gastrointestinal transit in vivo, leukocyte infiltration, and gastric emptying were analyzed. We also investigated the effects of the 5-HT3 receptor agonist m-chlorophenylbiguamide (mCPBG) and ghrelin-receptor antagonist [d-Lys3]-GHRP-6 on the ameliorative action of RKT. RKT treatment led to recovery of the delayed intestinal transit and gastric emptying rate induced by IM. RKT significantly inhibited the infiltration of neutrophils and macrophages. [d-Lys3]-GHRP-6 reduced and mCPBG partially reduced the RKT-mediated anti-inflammatory activity, as monitored by infiltrating macrophages and neutrophils. RKT serves as a novel therapeutic agent for POI characterized by its anti-inflammatory potency, in addition to prokinetic action. The RKT-induced anti-inflammatory activity may be partly mediated by inhibition of the 5-HT3 receptor and ghrelin release.
Journal
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- Journal of Pharmacological Sciences
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Journal of Pharmacological Sciences 124 (3), 374-385, 2014
The Japanese Pharmacological Society
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Details 詳細情報について
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- CRID
- 1390282680157590144
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- NII Article ID
- 130003391491
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- NII Book ID
- AA11806667
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- COI
- 1:CAS:528:DC%2BC2cXlsF2ms7Y%3D
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- ISSN
- 13478648
- 13478613
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- NDL BIB ID
- 025362582
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- PubMed
- 24572814
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed