Current Perspective : Protective Effects of Phytochemical Antioxidants Against Neurotoxin-Induced Degeneration of Dopaminergic Neurons

• Kita Taizo

  Laboratory of Pharmacology, Kyushu Nutrition Welfare University, School of Health Science, Japan

• Asanuma Masato

  Department of Brain Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan

• Miyazaki Ikuko

  Department of Brain Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan

• Takeshima Mika

  Department of Brain Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan Division of Nutrition, Ehime University Hospital, Japan

書誌事項

タイトル別名

• Protective Effects of Phytochemical Antioxidants Against Neurotoxin-Induced Degeneration of Dopaminergic Neurons

抄録

The specific toxicity to dopaminergic neurons of psychostimulants and neurotoxins has been extensively studied in vivo and in vitro, and findings have been used to establish animal models of amphetamine psychosis or Parkinson’s disease. The multiple mechanisms of neurotoxicity operating in these disorders are known to involve oxidative stress or neuroinflammation, producing the characteristic behavioral and neuropathlogical changes arising from injured dopaminergic neurons and glial cells. A number of studies have shown that glia-targeting antioxidants play important roles in protecting against the neurotoxicity caused by psychostimulants or neurotoxins. Phytochemicals, which are non-nutritive plant chemicals, protect dopaminergic neurons and glial cells from damage caused by psychostimulants or neurotoxins. The objective of this review was to evaluate the involvement of glial cells in dopaminergic neuron–specific toxicity and to explore the neuroprotective activity of phytochemicals in terms of anti-inflammatory and antioxidant action.

収録刊行物

• Journal of Pharmacological Sciences

  Journal of Pharmacological Sciences 124 (3), 313-319, 2014

  公益社団法人 日本薬理学会

キーワード

• dopaminergic neurotoxicity
• psychostimulant
• neurotoxin
• phytochemical

詳細情報

• CRID: 1390282680157582080
• NII論文ID: 130003391501
• NII書誌ID: AA11806667
• DOI: 10.1254/jphs.13r19cp
• COI: 1:CAS:528:DC%2BC2cXlsF2ms78%3D
• ISSN: 13478648
• ISSN: 13478613
• NDL書誌ID: 025362326
• PubMed: 24599140
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I025362326
• Web Site: https://www.jstage.jst.go.jp/article/jphs/124/3/124_13R19CP/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2015017182
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可