Diabetic Complications in Obese Type 2 Diabetic Rat Models

• Katsuda Yoshiaki

  Japan Tobacco Inc., Central Pharmaceutical Research Institute, 1–1 Murasaki-cho, Takatsuki, Osaka 569-1125, Japan

• Ohta Takeshi

  Japan Tobacco Inc., Central Pharmaceutical Research Institute, 1–1 Murasaki-cho, Takatsuki, Osaka 569-1125, Japan

• Miyajima Katsuhiro

  Japan Tobacco Inc., Central Pharmaceutical Research Institute, 1–1 Murasaki-cho, Takatsuki, Osaka 569-1125, Japan

• Kemmochi Yusuke

  Japan Tobacco Inc., Central Pharmaceutical Research Institute, 1–1 Murasaki-cho, Takatsuki, Osaka 569-1125, Japan

• Sasase Tomohiko

  Japan Tobacco Inc., Central Pharmaceutical Research Institute, 1–1 Murasaki-cho, Takatsuki, Osaka 569-1125, Japan

• Tong Bin

  Laboratory of Animal Genetics, Graduate School of Science and Technology, Niigata University, Nishi-ku, Niigata 950-2181, Japan

• Shinohara Masami

  CLEA Japan Inc., Planning and Development Section, 1–2–7 Higashiyama, Meguro-ku, Tokyo 153-8533, Japan

• Yamada Takahisa

  Laboratory of Animal Genetics, Graduate School of Science and Technology, Niigata University, Nishi-ku, Niigata 950-2181, Japan

抄録

We overviewed the pathophysiological features of diabetes and its complications in obese type 2 diabetic rat models: Otsuka Long-Evans Tokushima fatty (OLETF) rat, Wistar fatty rat, Zucker diabetic fatty (ZDF) rat and Spontaneously diabetic Torii (SDT) fatty rat. Pancreatic changes with progression of diabetes were classified into early changes, such as islet hypertrophy and degranulation of β cells, and degenerative changes, such as islet atrophy and fibrosis of islet with infiltration of inflammatory cells. Renal lesions in tubuli and glomeruli were observed, and nodular lesions in glomeruli were notable changes in OLETF and SDT fatty rats. Among retinal changes, folding and thickening were interesting findings in SDT fatty rats. A decrease of motor nerve conduction velocity with progression of diabetes was presented in obese diabetic rats. Other diabetic complications, osteoporosis and sexual dysfunction, were also observed. Observation of bone metabolic abnormalities, including decrease of osteogenesis and bone mineral density, and sexual dysfunction, including hypotestosteronemia and erectile dysfunction, in obese type 2 diabetic rats have been reported.

収録刊行物

• Experimental Animals

  Experimental Animals 63 (2), 121-132, 2014

  公益社団法人 日本実験動物学会

キーワード

• animal model
• diabetes
• diabetic complication
• obese
• SDT fatty rat

詳細情報

• CRID: 1390282680020750080
• NII論文ID: 130003391622
• NII書誌ID: AA11032321
• DOI: 10.1538/expanim.63.121
• COI: 1:STN:280:DC%2BC2cnntlOqtw%3D%3D
• ISSN: 18817122
• ISSN: 00075124
• ISSN: 13411357
• NDL書誌ID: 025412014
• PubMed: 24770637
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I025412014
• Web Site: https://www.jstage.jst.go.jp/article/expanim/63/2/63_13-0080/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2014344227
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可